Integrin αX/ITGAX/CD11c Antibody (B-Iy6): sc-19989
- Integrin αX/ITGAX/CD11c Antibody (B-Iy6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against a cell suspension of Integrin αX of a human with hairy cell leukemia
- recommended for detection of Integrin αX of human origin by IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See Integrin αX/ITGAX/CD11c (B-6): sc-46676 for Integrin αX/ITGAX/CD11c antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Integrin αX/ITGAX/CD11c Antibody (B-Iy6). These reagents are now offered in bundles with Integrin αX/ITGAX/CD11c Antibody (B-Iy6) (see ordering information below).
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Integrin αX Antibody (B-Iy6) is a mouse monoclonal IgG1 antibody that detects Integrin αX in human samples through immunofluorescence (IF) and flow cytometry (FCM) applications. Integrin αX is a type 1 transmembrane protein that plays a crucial role in the immune response by forming a leukocyte-specific integrin when combined with the β2 chain, known as the inactivated-C3b receptor 4 (CR4). Anti-Integrin αX antibody (B-Iy6) is essential for studying neutrophil and monocyte adherence to activated endothelial cells, as well as facilitating the phagocytosis of complement-coated particles, which is vital for clearing pathogens and debris from the body. Notably, abnormal expression of Integrin αX is associated with hairy cell leukemia, highlighting its significance in cancer biology and the activation of proto-oncogenes such as Ras and JunD. The transcription of Integrin αX is influenced by various proteins and DNA elements, including Sp1, AP-1 family members, and PU.1, which underscores the complexity of its regulation. Integrin αX is predominantly found on monocyte-derived dendritic cells, macrophages, and natural killer cells, and upon activation, dendritic cells, particularly those in the skin and mucosal tissues, can migrate to lymphoid organs to interact with T and B cells, thereby initiating and shaping adaptive immune responses. Integrin αX monoclonal antibody (B-Iy6) is an invaluable tool for researchers studying immune cell interactions and the underlying mechanisms of immune-related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Integrin αX/ITGAX/CD11c Antibody (B-Iy6) References:
- Integrin CD11c/CD18 α-chain phosphorylation is functionally important. | Uotila, LM., et al. 2013. J Biol Chem. 288: 33494-9. PMID: 24129562
- Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells. | Yang, R., et al. 2022. Sci Immunol. 7: eabq3277. PMID: 35867801
- The development and function of CD11c+ atypical B cells - insights from single cell analysis. | Gao, X. and Cockburn, IA. 2022. Front Immunol. 13: 979060. PMID: 36072594
- CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis. | Bauer, KM., et al. 2022. JCI Insight. 7: PMID: 36214220
- CD11c regulates late-stage T cell development in the thymus. | Hou, L. and Yuki, K. 2022. Front Immunol. 13: 1040818. PMID: 36439108
- CD11c+ macrophages are proangiogenic and necessary for experimental choroidal neovascularization. | Droho, S., et al. 2023. JCI Insight. 8: PMID: 36821388
- GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis. | Tsukui, D., et al. 2023. iScience. 26: 107293. PMID: 37520709
- CD11c+ macrophages mediate brain-to-gut α-synuclein trafficking. | Wood, H. 2024. Nat Rev Neurol. 20: 1. PMID: 38049638
- Identification of dendritic cell precursor from the CD11c+ cells expressing high levels of MHC class II molecules in the culture of bone marrow with FLT3 ligand. | In, H., et al. 2023. Front Immunol. 14: 1179981. PMID: 38094300
- CD11c+ B cells in relapsing-remitting multiple sclerosis and effects of anti-CD20 therapy. | El Mahdaoui, S., et al. 2024. Ann Clin Transl Neurol. 11: 926-937. PMID: 38332555
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin αX/ITGAX/CD11c Antibody (B-Iy6) | sc-19989 | 200 µg/ml | $322.00 | |||
Integrin αX/ITGAX/CD11c Antibody (B-Iy6): m-IgG Fc BP-HRP Bundle | sc-538907 | 200 µg Ab; 10 µg BP | $361.00 | |||
Integrin αX/ITGAX/CD11c Antibody (B-Iy6): m-IgG1 BP-HRP Bundle | sc-541140 | 200 µg Ab; 20 µg BP | $361.00 | |||
Integrin αX/ITGAX/CD11c Antibody (B-Iy6) FITC | sc-19989 FITC | 200 µg/ml | $336.00 | |||
Integrin αX/ITGAX/CD11c Antibody (B-ly6) PE | sc-19989 PE | 200 µg/ml | $349.00 |