Integrin αX/ITGAX/CD11c Antibody (3H986): sc-71456

Integrin αX Antibody (3H986) is a hamster monoclonal IgG antibody that detects Integrin αX in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. Integrin αX is a type 1 transmembrane protein that plays a crucial role in the immune system by forming a leukocyte-specific integrin when combined with the β2 chain, known as the inactivated-C3b receptor 4 (CR4). Anti-Integrin αX antibody (3H986) recognizes a protein essential for mediating the adherence of neutrophils and monocytes to activated endothelial cells, as well as facilitating the phagocytosis of complement-coated particles, which is vital for an effective immune response. Abnormal expression of Integrin αX is notably associated with hairy cell leukemia, highlighting its significance in cancer biology and the activation of proto-oncogenes such as Ras and JunD. The transcription of Integrin αX is influenced by various proteins and DNA elements, including Sp1, AP-1 family members, C/EBP, Oct-2, and PU.1, which underscores the complexity of its regulation. Integrin αX is predominantly found on monocyte-derived dendritic cells, macrophages, and natural killer cells, and upon activation, dendritic cells located in tissues such as the skin, lungs, and intestines can migrate to lymphoid tissues, where they interact with T and B cells to initiate and modulate the immune response.

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Integrin αX/ITGAX/CD11c Antibody (3H986) References:

1. CD11c expression in adipose tissue and blood and its role in diet-induced obesity.  |  Wu, H., et al. 2010. Arterioscler Thromb Vasc Biol. 30: 186-92. PMID: 19910635
2. Identification of Pathogenic Cardiac CD11c+ Macrophages in Nod1-Mediated Acute Coronary Arteritis.  |  Motomura, Y., et al. 2015. Arterioscler Thromb Vasc Biol. 35: 1423-33. PMID: 25838430
3. Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential.  |  Qualai, J., et al. 2016. PLoS One. 11: e0154253. PMID: 27119555
4. Expression pattern of CD11c on lung immune cells after disseminated murine cytomegalovirus infection.  |  Liao, Y., et al. 2017. Virol J. 14: 132. PMID: 28720115
5. Distinctly regulated functions and mobilization of CD11c-positive cells elicited by TLR3- and IPS-1 signaling in the cornea.  |  Ueta, M., et al. 2019. Immunol Lett. 206: 49-53. PMID: 30571996
6. Identification of HIV transmitting CD11c+ human epidermal dendritic cells.  |  Bertram, KM., et al. 2019. Nat Commun. 10: 2759. PMID: 31227717
7. CD11c+ dendritic cells mediate antigen-specific suppression in extracorporeal photopheresis.  |  Hackstein, H., et al. 2021. Clin Exp Immunol. 203: 329-339. PMID: 33073358
8. Conditional knockout of oestrogen receptor alpha in CD11c+ cells impacts female survival and inflammatory cytokine profile in murine lupus.  |  Lennard Richard, ML., et al. 2022. Immunology. 167: 354-367. PMID: 35778961
9. Lack of mTORC2 signaling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis.  |  Ignacio, A., et al. 2024. J Leukoc Biol. 116: 779-792. PMID: 38652699
10. Sp3 mediates transcriptional activation of the leukocyte integrin genes CD11C and CD11B and cooperates with c-Jun to activate CD11C.  |  Noti, JD. 1997. J Biol Chem. 272: 24038-45. PMID: 9295357

The preferred Integrin αX/ITGAX/CD11c antibody is Integrin αX/ITGAX/CD11c Antibody (B-6): sc-46676.