Integrin αM/CD11b Antibody (A-8): sc-515923

Integrin αM Antibody (A-8) is a mouse monoclonal IgG1 kappa light chain antibody engineered to target human Integrin αM, also known as CD11b, ITGAM, MAC1A, MO1A, and complement component receptor-3 α (CR3α). Integrin αM is a crucial cell adhesion molecule located on leukocyte surfaces, playing a vital role in immune system function by mediating adhesion and migration of immune cells to inflammatory sites. Integrin αM undergoes significant post-translational modifications, such as glycosylation, essential for proper folding, stability, and interaction with ligands like intracellular adhesion molecules (ICAMs). These modifications regulate binding affinity and specificity of Integrin αM, influencing processes like phagocytosis and cell signaling. Anti-Integrin αM antibody (A-8) specifically recognizes an epitope mapping between amino acids 1128-1152 at the C-terminus of Integrin αM, ensuring precise detection in various assays including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Integrin αM monoclonal antibody (A-8) is available in both non-conjugated and multiple conjugated forms, such as horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and Alexa Fluor® variants, providing versatility for diverse experimental applications. Anti-Integrin αM antibody (A-8) enables researchers to effectively study immune cell adhesion, migration, and pathogen clearance, offering valuable insights into immune responses and inflammatory diseases.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin αM/CD11b Antibody (A-8) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin αM/CD11b Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin αM/CD11b Antibody (A-8) Specifications

Alternate Product Name: Integrin αM

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1128-1152

Epitope Target: Integrin αM

Epitope Species: human

Product Reactivity/Detection: Integrin αM

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Integrin αM/CD11b Antibody (A-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.