Integrin αM Activators represent a specific group of chemical compounds recognized for their capability to modulate the activity of integrin alpha M (αM) receptors. This chemical class operates by interacting with and enhancing the signaling pathways associated with αM integrins, which are transmembrane cell adhesion receptors crucial for mediating cell-cell and cell-extracellular matrix interactions. Integrin αM receptors, also known as CD11b/CD18 or Mac-1, play essential roles in various biological processes, including immune cell adhesion, migration, and phagocytosis.
Integrin αM Activators exert their influence through specific molecular interactions that may amplify the downstream effects of αM integrin-mediated signaling, contributing to the fine-tuning of immune responses, cellular adhesion, and phagocytic activities. The intricate mechanisms through which Integrin αM Activators impact αM integrin-related pathways remain a focus of ongoing scientific investigation, providing insights into the complex interplay between cell adhesion, immune surveillance, and inflammatory processes. The specific ways in which this chemical class engages with Integrin αM receptors underscore its significance in unraveling the complexities of cell-matrix interactions and enhancing our understanding across various scientific domains.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a commonly used compound that activates protein kinase C (PKC) pathways, leading to integrin αM activation. PKC activation triggers intracellular signaling events that influence integrin affinity and binding to ligands | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS is a component of bacterial cell walls that can stimulate immune responses. It has been shown to induce integrin αM activation on monocytes and macrophages | ||||||
GM-CSF | 83869-56-1 | sc-280759 | 5 µg | $516.00 | 1 | |
Cytokines like granulocyte-macrophage colony-stimulating factor (GM-CSF) can activate integrin αM. GM-CSF promotes the growth and activation of immune cells. | ||||||