Integrin αIIb/β3/CD41/CD61 Antibody (IVA30): sc-51656

Integrin αIIb/β3 Antibody (IVA30) is a mouse monoclonal IgG2 antibody designed to target the Integrin αIIb/β3 protein, also known as GPIIb/IIIa or CD41/CD61, which is prominently located on the surface of bovine thrombocytes. Anti-Integrin αIIb/β3 antibody (IVA30) is meticulously raised against bovine thrombocytes, ensuring precise binding and effective detection in applications such as immunoprecipitation (IP) and flow cytometry (FCM). Integrin αIIb/β3 is a vital transmembrane heterodimer composed of αIIb and β3 subunits, playing a critical role in platelet aggregation by mediating the binding of platelets to fibrinogen and other extracellular matrix proteins, which is essential for the formation and stabilization of blood clots during hemostasis. The cell surface localization of Integrin αIIb/β3 is crucial as this placement facilitates direct interactions with circulating ligands, enabling rapid platelet responses necessary for wound healing and vascular injury repair. Beyond a role in cell adhesion, Integrin αIIb/β3 functions as a key signaling receptor that transduces signals influencing various cellular processes such as platelet activation, spreading, growth, differentiation, migration, and apoptosis. This dual functionality underscores Integrin αIIb/β3′s importance in both normal physiological functions and pathological conditions, including blood clotting disorders and cardiovascular diseases. By providing robust detection of Integrin αIIb/β3, Integrin αIIb/β3 monoclonal antibody (IVA30) facilitates advanced research into thrombocyte biology, platelet function, and the molecular mechanisms governing blood coagulation, making this reagent an indispensable tool for researchers focused on veterinary hematology and related biomedical fields.

The preferred Integrin αV/β3/CD51/CD61 antibody is Integrin αV/β3/CD51/CD61 Antibody (23C6): sc-7312.