Integrin αIIb/β3/CD41/CD61 Antibody (474): sc-52816

Integrin αIIb/β3 Antibody (474) is a mouse monoclonal IgG1 kappa light chain antibody engineered to recognize integrin αIIb/β3 protein, also known as GPIIb/IIIa or CD41/CD61, which is predominantly expressed on the surface of human platelets. Anti-integrin αIIb/β3 antibody (474) is meticulously raised against human platelets, ensuring precise binding and effective detection in applications such as western blotting (WB) and immunoprecipitation (IP). Integrin αIIb/β3 is a crucial heterodimeric transmembrane receptor composed of αIIb and β3 subunits, whose intricate structural configuration is essential for mediating platelet aggregation and thrombus formation. The protein′s structure includes large extracellular domains responsible for ligand binding, a single transmembrane region, and short cytoplasmic tails that interact with the cytoskeleton and signaling molecules. Post-translational modifications (PTMs) of integrin αIIb/β3, such as glycosylation and phosphorylation, are critical for proper folding, stability, and function. Glycosylation of the extracellular domains enhances ligand affinity and specificity, facilitating the binding of fibrinogen and other extracellular matrix proteins, which is vital for the formation and stabilization of blood clots during hemostasis. Phosphorylation of the cytoplasmic tails regulates the activation state of integrin αIIb/β3, modulating its ability to transduce signals that influence platelet activation, spreading, and aggregation. These PTMs are indispensable for the dynamic regulation of integrin αIIb/β3, allowing for effective response to physiological and pathological stimuli. Anti-integrin αIIb/β3 antibody (474) is recommended for researchers studying molecular mechanisms governing platelet function, cellular adhesion, and signal transduction pathways.

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Integrin αIIb/β3/CD41/CD61 Antibody (474) References:

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The preferred Integrin αV/β3/CD51/CD61 antibody is Integrin αV/β3/CD51/CD61 Antibody (23C6): sc-7312.