Integrin αIIb/ITGA2B/CD41 Antibody (M-148): sc-7310

Integrin αIIb Antibody (M-148) is a mouse monoclonal IgG2a antibody that detects Integrin αIIb of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-Integrin αIIb antibody (M-148) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Integrin αIIb is a crucial component of the integrin family, which consists of heterodimers formed by noncovalently associated transmembrane α and β subunits. Specifically, Integrin αIIb pairs with β3 to form the integrin receptor known as αIIbβ3, which is predominantly expressed on platelets and plays a vital role in hemostasis and thrombosis. This receptor is essential for platelet aggregation, as αIIbβ3 binds to fibrinogen and other adhesive proteins, facilitating the formation of a stable platelet plug during blood clotting. Proper functioning of Integrin αIIb is critical for maintaining vascular integrity and preventing excessive bleeding, making Integrin αIIb a significant target for therapeutic interventions in cardiovascular diseases. Additionally, integrins like αIIbβ3 are involved in various signaling pathways that influence cell survival, migration, and differentiation, underscoring their importance in both normal physiology and pathological conditions.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin αIIb/ITGA2B/CD41 Antibody (M-148) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin αIIb/ITGA2B/CD41 Antibody (M-148) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin αIIb/ITGA2B/CD41 Antibody (M-148) Specifications

Alternate Product Name: Integrin αIIb

Product Clone Name: M-148

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Integrin αIIb

Epitope Species: mouse

Product Reactivity/Detection: Integrin αIIb

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for Integrin αIIb/ITGA2B/CD41 Antibody (M-148): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Integrin αIIb/ITGA2B/CD41 antibody is Integrin αIIb/ITGA2B/CD41 Antibody (MWReg30): sc-19963.