Integrin α6/ITGA6/CD49f Antibody (mAB-5A): sc-59920

Integrin α6 Antibody (mAB-5A) is a mouse monoclonal IgG1 kappa light chain antibody raised against rat Integrin α6, designed to detect Integrin α6 in mouse and rat samples by immunofluorescence (IF) and flow cytometry (FCM), with no cross-reactivity to rat fibroblasts. Integrin α6, also known as ITGA6 or CD49f, is a transmembrane protein that forms heterodimers with β subunits, particularly β1 and β4, to mediate cell adhesion to the extracellular matrix through interactions with laminin. Integrin α6 interacts with various molecules such as tetraspanin CD151, which modulates localization and enhances stability, and intracellular signaling proteins like focal adhesion kinase (FAK) and phosphoinositide 3-kinase (PI3K), which are crucial for signal transduction pathways regulating cell migration, proliferation, and survival. These interactions influence cellular responses to the environment and play roles in processes like wound healing and cancer metastasis. Anti-Integrin α6 antibody (mAB-5A) serves as a valuable tool for researchers studying cell adhesion mechanisms, signal transduction pathways, and the role of integrins in health and disease. Integrin α6 monoclonal antibody (mAB-5A) enhances the ability to investigate molecular interactions and functions of Integrin α6, contributing to a deeper understanding of biological processes.

The preferred Integrin α6/ITGA6/CD49f antibody is Integrin α6/ITGA6/CD49f Antibody (GOH3): sc-19622.