Integrin α6/ITGA6/CD49f Antibody (F-6): sc-374057

Integrin α6 Antibody (F-6) is a mouse monoclonal IgM kappa light chain antibody designed to target an epitope located between amino acids 24-50 at the N-terminus of the human Integrin α6 protein, also known as CD49f or ITGA6. Integrin α6 monoclonal antibody (F-6) demonstrates broad species reactivity, effectively recognizing the Integrin α6 heavy chain in mouse, rat, and human samples across various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Integrin α6 plays a pivotal role in cell adhesion and signaling by forming heterodimers with β1 or β4 subunits, facilitating interactions with extracellular matrix proteins such as laminins, fibronectin, collagen, and vitronectin. Additionally, Integrin α6 interacts with intracellular proteins like talin and kindlin, which are essential for linking integrins to the actin cytoskeleton and initiating downstream signaling pathways. These interactions are crucial for processes including cell migration, differentiation, proliferation, and apoptosis. The ability of Integrin α6 to engage with various binding partners underscores its importance in maintaining cellular architecture and facilitating communication between cells and their environment. Integrin α6 (F-6) antibody serves as an indispensable tool for researchers investigating the molecular mechanisms of integrin-mediated functions and their implications in diseases such as cancer, where Integrin α6 is often implicated in tumor progression and metastasis. By targeting a specific extracellular region, anti-Integrin α6 antibody (F-6) enables precise detection and analysis of Integrin α6, contributing to a deeper understanding of its role in cellular physiology and pathology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin α6/ITGA6/CD49f Antibody (F-6) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin α6/ITGA6/CD49f Antibody (F-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin α6/ITGA6/CD49f Antibody (F-6) Specifications

Alternate Product Name: Integrin α6

Product Clone Name: F-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 24-50

Epitope Target: Integrin α6

Epitope Species: human

Product Reactivity/Detection: Integrin α6 heavy chain

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for Integrin α6/ITGA6/CD49f Antibody (F-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF647: Alexa Fluor^® 647, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Integrin α6/ITGA6/CD49f antibody is Integrin α6/ITGA6/CD49f Antibody (GOH3): sc-19622.