Integrin α6/ITGA6/CD49f Antibody (mAB-5A): sc-59920

Integrin α6 Antibody (mAB-5A) is a mouse monoclonal IgG1 kappa light chain antibody raised against rat Integrin α6, designed to detect Integrin α6 in mouse and rat samples by immunofluorescence (IF) and flow cytometry (FCM), with no cross-reactivity to rat fibroblasts. Integrin α6, also known as ITGA6 or CD49f, is a transmembrane protein that forms heterodimers with β subunits, particularly β1 and β4, to mediate cell adhesion to the extracellular matrix through interactions with laminin. Integrin α6 interacts with various molecules such as tetraspanin CD151, which modulates localization and enhances stability, and intracellular signaling proteins like focal adhesion kinase (FAK) and phosphoinositide 3-kinase (PI3K), which are crucial for signal transduction pathways regulating cell migration, proliferation, and survival. These interactions influence cellular responses to the environment and play roles in processes like wound healing and cancer metastasis. Anti-Integrin α6 antibody (mAB-5A) serves as a valuable tool for researchers studying cell adhesion mechanisms, signal transduction pathways, and the role of integrins in health and disease. Integrin α6 monoclonal antibody (mAB-5A) enhances the ability to investigate molecular interactions and functions of Integrin α6, contributing to a deeper understanding of biological processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Integrin α6/ITGA6/CD49f Antibody (mAB-5A) References:

1. Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion.  |  He, B., et al. 2005. J Biol Chem. 280: 3346-54. PMID: 15557282
2. Integrin alpha6 cleavage: a novel modification to modulate cell migration.  |  Pawar, SC., et al. 2007. Exp Cell Res. 313: 1080-9. PMID: 17303120
3. Parathyroid hormone-related protein regulates integrin α6 and β4 levels via transcriptional and post-translational pathways.  |  Bhatia, V., et al. 2013. Exp Cell Res. 319: 1419-30. PMID: 23499737
4. miR-542-5p Attenuates Fibroblast Activation by Targeting Integrin α6 in Silica-Induced Pulmonary Fibrosis.  |  Yuan, J., et al. 2018. Int J Mol Sci. 19: PMID: 30467286
5. Hypoxia-induced PIM kinase and laminin-activated integrin α6 mediate resistance to PI3K inhibitors in bone-metastatic CRPC.  |  Toth, RK., et al. 2019. Am J Clin Exp Urol. 7: 297-312. PMID: 31511835
6. Shengjing Capsule Improves Spermatogenesis through Upregulating Integrin α6/β1 in the NOA Rats.  |  Wang, J., et al. 2019. Evid Based Complement Alternat Med. 2019: 8494567. PMID: 31534468
7. UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway.  |  Yuan, M., et al. 2020. Int J Oncol. 56: 139-150. PMID: 31789389
8. Extrinsic modulation of integrin α6 and progenitor cell behavior in mesenchymal stem cells.  |  Nieto-Nicolau, N., et al. 2020. Stem Cell Res. 47: 101899. PMID: 32659733
9. An optimized integrin α6-targeted peptide for positron emission tomography/magnetic resonance imaging of pancreatic cancer and its precancerous lesion.  |  Mei, Y., et al. 2020. Clin Transl Med. 10: e157. PMID: 32898323
10. Development and preclinical evaluation of a cyclic PET tracer targeting integrin-α6 on colorectal cancer models.  |  Chen, L., et al. 2024. Bioorg Chem. 153: 107892. PMID: 39447346

The preferred Integrin α6/ITGA6/CD49f antibody is Integrin α6/ITGA6/CD49f Antibody (GOH3): sc-19622.