Integrin α6/ITGA6/CD49f Antibody (541A11): sc-47772

Integrin α6 Antibody (541A11) is a mouse monoclonal IgM kappa light chain antibody raised against recombinant human Integrin α6, designed to detect Integrin α6 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Integrin α6, also known as ITGA6 or CD49f, is a transmembrane protein that pairs with β subunits, specifically β1 or β4, to form heterodimers like α6β1 and α6β4, which are crucial for cell adhesion to the extracellular matrix through binding to laminin. Integrin α6 protein′s structure features a large extracellular domain responsible for ligand binding, a single transmembrane helix, and a short cytoplasmic tail that interacts with intracellular signaling molecules and cytoskeletal proteins such as talin and vinculin. This structural configuration is essential for its role in bidirectional signal transduction between the cell interior and its external environment. The integrity of Integrin α6′s structure is vital for processes such as cell migration, proliferation, differentiation, and survival, as Integrin α6 mediates both mechanical anchoring and the activation of signaling pathways. Dysregulation or altered expression of Integrin α6 has been implicated in various pathological conditions, including cancer progression and metastasis, highlighting its importance in biomedical research. Anti-Integrin α6 antibody (541A11) is available in non-conjugated form and is a valuable tool for investigating Integrin α6′s role in cellular functions and disease mechanisms. By accurately detecting Integrin α6 across multiple species, Integrin α6 monoclonal antibody (541A11) aids researchers in studying cell adhesion, signaling pathways, and the impact of integrins on health and disease.

The preferred Integrin α6/ITGA6/CD49f antibody is Integrin α6/ITGA6/CD49f Antibody (GOH3): sc-19622.