Integrin α6/ITGA6/CD49f Antibody (3H1512): sc-71423

Integrin α6 Antibody (3H1512) is a mouse monoclonal IgG1 kappa light chain antibody raised against integrin α6/β4 from A-431 cells of human origin. Anti-integrin α6 antibody (3H1512) specifically recognizes integrin α6, also known as CD49f or ITGA6, in human samples by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin α6 is a transmembrane glycoprotein that pairs with β4 or β1 subunits to form heterodimeric receptors like α6β4 and α6β1, which are essential for binding to laminin in the extracellular matrix. Structurally, integrin α6 consists of a large extracellular domain for ligand binding, a single transmembrane domain, and a short cytoplasmic tail that interacts with intracellular signaling molecules and adaptor proteins, such as talin and vinculin, linking integrin α6 to the actin cytoskeleton. This structural configuration enables integrin α6 to mediate cell adhesion, migration, and signal transduction, playing a vital role in maintaining tissue integrity and cellular communication. Alterations in the structure or expression of integrin α6, particularly in epithelial-to-mesenchymal transition (EMT), can significantly impact biological processes such as wound healing, embryonic development, and cancer progression. Integrin α6 monoclonal antibody (3H1512) serves as a valuable tool for researchers studying cell adhesion, migration, and related signaling pathways in developmental biology, oncology, and other fields.

The preferred Integrin α6/ITGA6/CD49f antibody is Integrin α6/ITGA6/CD49f Antibody (GOH3): sc-19622.