Integrin α6/ITGA6/CD49f Antibody (2Q959): sc-71427

Integrin α6 Antibody (2Q959) is a mouse monoclonal IgG2b kappa light chain antibody raised against the SW1222 colorectal cell line of human origin. Recognizing Integrin α6 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM), anti-Integrin α6 antibody (2Q959) is ideal for detecting Integrin α6 in various experimental applications. Integrin α6, also known as CD49f, is a transmembrane glycoprotein located on the cell surface, specifically within the plasma membrane, and is often found in specialized membrane structures like hemidesmosomes in epithelial cells. Integrin α6 pairs with β1 or β4 integrin subunits to form receptors such as α6β1 and α6β4, which bind to laminin, a major component of the basement membrane. The localization of Integrin α6 at the cell surface is crucial for mediating cell adhesion to the extracellular matrix, influencing cell signaling pathways that regulate proliferation, migration, differentiation, and survival. By anchoring cells to the basement membrane, Integrin α6 plays a significant role in maintaining tissue integrity and architecture. Alterations in Integrin α6 expression or function, particularly in its association with β4, have been implicated in various pathological conditions, including cancer progression, epithelial-to-mesenchymal transition (EMT), and metastasis. Integrin α6 (2Q959) antibody allows for specific detection and analysis of Integrin α6, facilitating research in fields such as oncology, developmental biology, and cell biology.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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Integrin α6/ITGA6/CD49f Antibody (2Q959) References:

1. Laminin alpha4 and integrin alpha6 are upregulated in regenerating dy/dy skeletal muscle: comparative expression of laminin and integrin isoforms in muscles regenerating after crush injury.  |  Sorokin, LM., et al. 2000. Exp Cell Res. 256: 500-14. PMID: 10772822
2. Downregulated expression of integrin alpha6 by transforming growth factor-beta(1) on lens epithelial cells in vitro.  |  Lim, JM., et al. 2001. Biochem Biophys Res Commun. 284: 33-41. PMID: 11374867
3. TAF4b and Jun/activating protein-1 collaborate to regulate the expression of integrin alpha6 and cancer cell migration properties.  |  Kalogeropoulou, M., et al. 2010. Mol Cancer Res. 8: 554-68. PMID: 20353996
4. Heterogeneity of mouse primordial germ cells reflecting the distinct status of their differentiation, proliferation and apoptosis can be classified by the expression of cell surface proteins integrin α6 and c-Kit.  |  Morita-Fujimura, Y., et al. 2009. Dev Growth Differ. 51: 567-83. PMID: 21314674
5. Glioma stem cell invasion through regulation of the interconnected ERK, integrin α6 and N-cadherin signaling pathway.  |  Velpula, KK., et al. 2012. Cell Signal. 24: 2076-84. PMID: 22789454
6. Differential Expression Levels of Integrin α6 Enable the Selective Identification and Isolation of Atrial and Ventricular Cardiomyocytes.  |  Wiencierz, AM., et al. 2015. PLoS One. 10: e0143538. PMID: 26618511
7. Exclusive expression of the Rab11 effector SH3TC2 in Schwann cells links integrin-α6 and myelin maintenance to Charcot-Marie-Tooth disease type 4C.  |  Vijay, S., et al. 2016. Biochim Biophys Acta. 1862: 1279-90. PMID: 27068304
8. α6 Integrin (α6high)/Transferrin Receptor (CD71)low Keratinocyte Stem Cells Are More Potent for Generating Reconstructed Skin Epidermis Than Rapid Adherent Cells.  |  Metral, E., et al. 2017. Int J Mol Sci. 18: PMID: 28134816
9. Long noncoding RNA opa-interacting protein 5 antisense transcript 1 promotes proliferation and invasion through elevating integrin α6 expression by sponging miR-143-3p in cervical cancer.  |  Yang, J., et al. 2019. J Cell Biochem. 120: 907-916. PMID: 30188591
10. Retroviral transfer of antisense integrin alpha6 or alpha8 sequences results in laminar redistribution or clonal cell death in developing brain.  |  Zhang, Z. and Galileo, DS. 1998. J Neurosci. 18: 6928-38. PMID: 9712662

The preferred Integrin α6/ITGA6/CD49f antibody is Integrin α6/ITGA6/CD49f Antibody (GOH3): sc-19622.