Integrin α6/ITGA6/CD49f Antibody (2Q959): sc-71427

Integrin α6 Antibody (2Q959) is a mouse monoclonal IgG2b kappa light chain antibody raised against the SW1222 colorectal cell line of human origin. Recognizing Integrin α6 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM), anti-Integrin α6 antibody (2Q959) is ideal for detecting Integrin α6 in various experimental applications. Integrin α6, also known as CD49f, is a transmembrane glycoprotein located on the cell surface, specifically within the plasma membrane, and is often found in specialized membrane structures like hemidesmosomes in epithelial cells. Integrin α6 pairs with β1 or β4 integrin subunits to form receptors such as α6β1 and α6β4, which bind to laminin, a major component of the basement membrane. The localization of Integrin α6 at the cell surface is crucial for mediating cell adhesion to the extracellular matrix, influencing cell signaling pathways that regulate proliferation, migration, differentiation, and survival. By anchoring cells to the basement membrane, Integrin α6 plays a significant role in maintaining tissue integrity and architecture. Alterations in Integrin α6 expression or function, particularly in its association with β4, have been implicated in various pathological conditions, including cancer progression, epithelial-to-mesenchymal transition (EMT), and metastasis. Integrin α6 (2Q959) antibody allows for specific detection and analysis of Integrin α6, facilitating research in fields such as oncology, developmental biology, and cell biology.

The preferred Integrin α6/ITGA6/CD49f antibody is Integrin α6/ITGA6/CD49f Antibody (GOH3): sc-19622.