Integrin α3/ITGA3/CD49c Antibody (VM-2): sc-32237

Integrin α3 Antibody (VM-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Integrin α3 protein of human origin by flow cytometry (FCM). Anti-Integrin α3 antibody (VM-2) plays a crucial role in understanding the function of integrins, which are essential for mediating cell adhesion and signaling. Integrin α3, also known as very late activation antigen 3 (VLA-3), is primarily located on the cell surface, where Integrin α3 forms heterodimers with β1 subunits to create functional receptors that interact with various extracellular matrix proteins. This interaction is vital for maintaining tissue integrity and facilitating cellular communication, as Integrin α3 influences processes such as cell migration, proliferation, and differentiation. Integrin α3′s ability to bind ligands like fibronectin and collagen underscores its importance in cellular responses to the extracellular environment. Furthermore, Integrin α3′s post-translational modifications, including cleavage in the extracellular domain, result in the formation of disulfide-linked light and heavy chains, which are critical for structural integrity and functional versatility. Integrin α3 monoclonal antibody (VM-2) enables researchers to gain valuable insights into the mechanisms of cell adhesion and signaling pathways that are fundamental to various biological processes.

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Integrin α3/ITGA3/CD49c Antibody (VM-2) References:

1. Induction of alpha-catenin, integrin alpha3, integrin beta6, and PDGF-B by 2,8-dihydroxyadenine crystals in cultured kidney epithelial cells.  |  Wang, L., et al. 2002. Exp Nephrol. 10: 365-73. PMID: 12381921
2. Integrin-alpha3 mediates binding of Chordin to the cell surface and promotes its endocytosis.  |  Larraín, J., et al. 2003. EMBO Rep. 4: 813-8. PMID: 12897802
3. Upregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) mice.  |  Steenhard, BM., et al. 2012. PLoS One. 7: e50745. PMID: 23236390
4. Crucial role of posttranslational modifications of integrin α3 in interstitial lung disease and nephrotic syndrome.  |  Yalcin, EG., et al. 2015. Hum Mol Genet. 24: 3679-88. PMID: 25810266
5. Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells.  |  Tomellini, E., et al. 2019. Cell Rep. 28: 1063-1073.e5. PMID: 31340144
6. A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells.  |  Choi, DH., et al. 2020. Stem Cell Res Ther. 11: 359. PMID: 32807231
7. Cryptic ligand on collagen matrix unveiled by MMP13 accelerates bone tissue regeneration via MMP13/Integrin α3/RUNX2 feedback loop.  |  Arai, Y., et al. 2021. Acta Biomater. 125: 219-230. PMID: 33677160
8. Integrin α3 mutation junctional epidermolysis bullosa presenting with hypotrichosis and lacrimal obstruction.  |  Alshihry, H., et al. 2024. JAAD Case Rep. 43: 76-79. PMID: 38223367
9. Sialyl Lewis X decorated integrin α3 on small extracellular vesicles promotes metastasis of bladder cancer via enhancing vascular permeability.  |  Feng, H., et al. 2024. Angiogenesis. 27: 883-901. PMID: 39222273
10. Caveolin-1 knockout mitigates breast cancer metastasis to the lungs via integrin α3 dysregulation in 4T1-induced syngeneic breast cancer model.  |  Singh, DP., et al. 2024. Cancer Gene Ther. 31: 1658-1668. PMID: 39244591

The preferred Integrin α3/ITGA3/CD49c antibody is Integrin α3/ITGA3/CD49c Antibody (A-3): sc-374242.