Integrin α3/ITGA3/CD49c Antibody (A-3): sc-374242

Integrin α3 Antibody (A-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects Integrin alpha 3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Integrin α3 (A-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Integrin alpha 3 protein, also known as very late activation antigen 3 (VLA-3), plays a crucial role in cell adhesion and signaling as a key component of the extracellular matrix receptor family. Integrin alpha 3 is primarily located on the cell surface, where forming heterodimers with β1 subunits facilitates interactions with extracellular matrix components such as fibronectin and collagen. Proper localization of Integrin alpha 3 maintains tissue architecture and mediates cellular responses to the extracellular environment. Binding to various ligands promotes cell adhesion and triggers intracellular signaling pathways that influence cell growth, differentiation, and migration. Additionally, Integrin alpha 3 chain undergoes post-translational modifications, including cleavage in the extracellular domain, essential for functional integrity and interaction with other proteins. Using anti-Integrin alpha 3 antibody (A-3) in research provides valuable insights into cell adhesion and signaling mechanisms, contributing to better understanding of various biological processes and disease states.

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Integrin α3/ITGA3/CD49c Antibody (A-3) References:

1. Structural requirement of carboxyl-terminal globular domains of laminin alpha 3 chain for promotion of rapid cell adhesion and migration by laminin-5.  |  Hirosaki, T., et al. 2000. J Biol Chem. 275: 22495-502. PMID: 10801807
2. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
3. Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3.  |  Tsuji, T., et al. 1991. J Biochem. 109: 659-65. PMID: 1714443
4. Roles of VLA-2 and VLA-3 on the formation of peritoneal dissemination in gastric cancer.  |  Yonemura, Y., et al. 1996. Int J Oncol. 8: 925-31. PMID: 21544447
5. Integrin α3 mutations with kidney, lung, and skin disease.  |  Has, C., et al. 2012. N Engl J Med. 366: 1508-14. PMID: 22512483
6. Branching morphogenesis of human mammary epithelial cells in collagen gels.  |  Berdichevsky, F., et al. 1994. J Cell Sci. 107 (Pt 12): 3557-68. PMID: 7535787
7. Specific association of CD63 with the VLA-3 and VLA-6 integrins.  |  Berditchevski, F., et al. 1995. J Biol Chem. 270: 17784-90. PMID: 7629079
8. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
9. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
10. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
11. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069
12. The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization.  |  de Melker, AA., et al. 1997. Lab Invest. 76: 547-63. PMID: 9111516

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin α3/ITGA3/CD49c Antibody (A-3) has 27 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin α3/ITGA3/CD49c Antibody (A-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin α3/ITGA3/CD49c Antibody (A-3) Specifications

Alternate Product Name: Integrin α3

Product Clone Name: A-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1029-1051

Epitope Target: Integrin α3

Epitope Species: human

Product Reactivity/Detection: Integrin α3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 27 citations in various scientific publications

Available Conjugates/Forms for Integrin α3/ITGA3/CD49c Antibody (A-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin