Integrin α2/ITGA2/CD49b Antibody (HAS-4): sc-53353

Integrin α2 (HAS-4) is a mouse monoclonal IgG2a antibody. Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The sixteen α and eight β subunits combine to produce more than 20 different receptors. Most integrin receptors bind to extracellular matrix components, including Fibronectin, collagen, and Vitronectin. Some integrin receptors also bind to soluble ligands like fibrinogen or counter-receptors on nearby cells, such as intracellular adhesion molecules (ICAMs), leading to cell aggregation. Ligands cross-link or cluster integrins by binding to adjacent integrin receptors, with both receptor clustering and ligand binding necessary for activating integrin-mediated responses. Beyond mediating cell adhesion and cytoskeletal organization, integrin receptors act as signal transducers. Integrin-mediated signals influence cell growth, differentiation, migration, and apoptosis. Integrin α2 enables platelets and other cells to adhere to collagens, while also regulating collagen and collagenase gene expression, force generation, and organization of newly formed extracellular matrix.

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Integrin α2/ITGA2/CD49b Antibody (HAS-4) References:

1. Allele-dependent transcriptional regulation of the human integrin alpha2 gene.  |  Jacquelin, B., et al. 2001. Blood. 97: 1721-6. PMID: 11238113
2. The alpha2beta1 integrin inhibitor rhodocetin binds to the A-domain of the integrin alpha2 subunit proximal to the collagen-binding site.  |  Eble, JA. and Tuckwell, DS. 2003. Biochem J. 376: 77-85. PMID: 12871211
3. Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway.  |  Sawhney, RS., et al. 2006. J Biol Chem. 281: 8497-510. PMID: 16461767
4. Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment.  |  Lee, SY., et al. 2006. Exp Cell Res. 312: 2983-99. PMID: 16828471
5. Identification of proteins that associate with integrin α2 by proteomic analysis in human fibrosarcoma HT-1080 cells.  |  Uematsu, T., et al. 2012. J Cell Physiol. 227: 3072-9. PMID: 21989839
6. Resistance to the mTOR-inhibitor RAD001 elevates integrin α2- and β1-triggered motility, migration and invasion of prostate cancer cells.  |  Tsaur, I., et al. 2012. Br J Cancer. 107: 847-55. PMID: 22782340
7. Laminin regulates the osteogenic differentiation of dental follicle cells via integrin-α2/-β1 and the activation of the FAK/ERK signaling pathway.  |  Viale-Bouroncle, S., et al. 2014. Cell Tissue Res. 357: 345-54. PMID: 24788823
8. Thrombospondin 4/integrin α2/HSF1 axis promotes proliferation and cancer stem-like traits of gallbladder cancer by enhancing reciprocal crosstalk between cancer-associated fibroblasts and tumor cells.  |  Shi, Y., et al. 2021. J Exp Clin Cancer Res. 40: 14. PMID: 33407730
9. MicroRNA miR-145-5p regulates cell proliferation and cell migration in colon cancer by inhibiting chemokine (C-X-C motif) ligand 1 and integrin α2.  |  Zhuang, W., et al. 2021. Bioengineered. 12: 9909-9917. PMID: 34860147
10. E-Cadherin, Integrin Alpha2 (Cd49b), and Transferrin Receptor-1 (Tfr1) Are Promising Immunohistochemical Markers of Selected Adverse Pathological Features in Patients Treated with Radical Prostatectomy.  |  Zapała, P., et al. 2021. J Clin Med. 10: PMID: 34884287

The preferred Integrin α2/ITGA2/CD49b antibody is Integrin α2/ITGA2/CD49b Antibody (C-9): sc-74466.