Integrin α2/ITGA2/CD49b Antibody (C-9): sc-74466

Integrin α2 Antibody (C-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Integrin alpha 2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Integrin alpha 2 antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Integrins, such as Integrin alpha 2, are crucial for mediating cell adhesion and play a significant role in cellular signaling pathways. Integrin alpha 2 is primarily located on the cell surface, where Integrin alpha 2 interacts with components of the extracellular matrix, particularly collagen. This localization allows Integrin alpha 2 to facilitate platelet and cell adhesion to collagen, essential for wound healing and tissue repair. Additionally, Integrin alpha 2 interaction with collagen triggers intracellular signaling cascades influencing cell behavior, including migration, proliferation, and survival. Integrin alpha 2 binding to collagen and mediating these responses highlights its importance in maintaining tissue integrity and facilitating cellular communication within the extracellular environment.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Integrin α2/ITGA2/CD49b Antibody (C-9) References:

1. The impact of the glycoprotein Ia collagen receptor subunit A1648G gene polymorphism on coronary artery disease and acute myocardial infarction.  |  Kroll, H., et al. 2000. Thromb Haemost. 83: 392-6. PMID: 10744142
2. The alpha2 Gene alleles of the platelet collagen receptor integrin alpha2 beta1 in Turkish children with cerebral infarct.  |  Akar, N., et al. 2001. Thromb Res. 102: 121-3. PMID: 11323022
3. Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2).  |  Arase, H., et al. 2001. J Immunol. 167: 1141-4. PMID: 11466327
4. 1H, 13C and 15N backbone resonance assignment of the integrin alpha2 I-domain.  |  Elshorst, B., et al. 2003. J Biomol NMR. 27: 191-2. PMID: 12913420
5. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
6. Platelet integrin alpha2 I-domain specific antibodies produced via domain specific DNA vaccination combined with variable gene phage display.  |  Hughes, DL., et al. 2005. Thromb Haemost. 94: 1318-26. PMID: 16411412
7. The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain.  |  Takada, Y. and Hemler, ME. 1989. J Cell Biol. 109: 397-407. PMID: 2545729
8. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
9. The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2).  |  Santoso, S., et al. 1993. J Clin Invest. 92: 2427-32. PMID: 7901236
10. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
11. Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice.  |  Moore, TA., et al. 1996. J Immunol. 157: 2366-73. PMID: 8805634
12. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin α2/ITGA2/CD49b Antibody (C-9) has 31 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin α2/ITGA2/CD49b Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin α2/ITGA2/CD49b Antibody (C-9) Specifications

Alternate Product Name: Integrin α2

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 840-1132

Epitope Target: Integrin α2

Epitope Species: human

Product Reactivity/Detection: Integrin α2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 31 citations in various scientific publications

Available Conjugates/Forms for Integrin α2/ITGA2/CD49b Antibody (C-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin