Integrin α2/ITGA2/CD49b Antibody (HAS-3): sc-53352

Integrin α2 Antibody (HAS-3) is a mouse monoclonal IgG2a light chain antibody that detects Integrin α2 in human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Integrin α2 plays a crucial role in mediating cell adhesion to collagen, which is essential for maintaining tissue integrity and facilitating communication between cells and the extracellular matrix. This interaction is particularly important in processes such as wound healing and tissue repair, where cell adhesion to collagen fibers influences migration and proliferation. Additionally, anti-Integrin α2 antibody (HAS-3) helps researchers study signaling pathways that regulate various cellular functions, including growth and differentiation, making Integrin α2 a key player in both normal physiological processes and pathological conditions such as cancer metastasis. Integrin α2 monoclonal antibody (HAS-3) provides a valuable tool for researchers studying these critical biological processes, enabling exploration of integrin roles in health and disease.

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Integrin α2/ITGA2/CD49b Antibody (HAS-3) References:

1. Significance of integrin alpha2/beta1 in peritoneal dissemination of a human gastric cancer xenograft model.  |  Kawamura, T., et al. 2001. Int J Oncol. 18: 809-15. PMID: 11251178
2. Integrin-using rotaviruses bind alpha2beta1 integrin alpha2 I domain via VP4 DGE sequence and recognize alphaXbeta2 and alphaVbeta3 by using VP7 during cell entry.  |  Graham, KL., et al. 2003. J Virol. 77: 9969-78. PMID: 12941907
3. Association of integrin alpha2 gene variants with ischemic stroke.  |  Matarin, M., et al. 2008. J Cereb Blood Flow Metab. 28: 81-9. PMID: 17534386
4. Increased expression of integrin alpha2 and abnormal response to TGF-beta1 in hereditary gingival fibromatosis.  |  Zhou, J., et al. 2009. Oral Dis. 15: 414-21. PMID: 19422573
5. The extracellular loop 2 of TM4SF5 inhibits integrin alpha2 on hepatocytes under collagen type I environment.  |  Lee, SA., et al. 2009. Carcinogenesis. 30: 1872-9. PMID: 19789264
6. Role of integrin α2 β1 in mediating osteoblastic differentiation on three-dimensional titanium scaffolds with submicron-scale texture.  |  Wang, X., et al. 2015. J Biomed Mater Res A. 103: 1907-18. PMID: 25203434
7. MicroRNA-128 inhibits EMT of human osteosarcoma cells by directly targeting integrin α2.  |  Liu, X., et al. 2016. Tumour Biol. 37: 7951-7. PMID: 26700675
8. Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2/β5/FAK signaling pathway.  |  Liu, F., et al. 2016. Oncotarget. 7: 8896-907. PMID: 26758421
9. Receptor activator of NF-κB ligand induces cell adhesion and integrin α2 expression via NF-κB in head and neck cancers.  |  Yamada, T., et al. 2016. Sci Rep. 6: 23545. PMID: 27009236
10. C-reactive protein binds to integrin α2 and Fcγ receptor I, leading to breast cell adhesion and breast cancer progression.  |  Kim, ES., et al. 2018. Oncogene. 37: 28-38. PMID: 28846105

The preferred Integrin α2/ITGA2/CD49b antibody is Integrin α2/ITGA2/CD49b Antibody (C-9): sc-74466.