Date published: 2025-10-20

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Integrin α11/ITGA11 Antibody (F-5): sc-390091

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Datasheets
  • Integrin α11/ITGA11 Antibody (F-5) is a mouse monoclonal IgG1 κ Integrin α11/ITGA11 antibody, cited in 3 publications, provided at 200 µg/ml
  • raised against amino acids 913-1151 mapping within an internal region of Integrin α11 of human origin
  • Integrin α11/ITGA11 Antibody (F-5) is recommended for detection of Integrin α11 of human origin by WB, IP, IF and ELISA
  • Anti-Integrin α11/ITGA11 Antibody (F-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
  • also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
  • also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Integrin α11/ITGA11 Antibody (F-5) for WB applications. These reagents are now offered in bundles with Integrin α11/ITGA11 Antibody (F-5) (see ordering information below).

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Integrin α11 Antibody (F-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Integrin alpha 11 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Integrin α11 antibody (F-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Integrin alpha 11, also known as ITGA11 or MSTP018, is a crucial component of the extracellular matrix, functioning primarily as a receptor for collagen. Integrin alpha 11 is a single-pass type I membrane protein composed of 1,189 amino acids, featuring one von Willebrand factor A (VWFA) domain and seven fibronectin type III (FG-GAP) repeats. Expression of Integrin alpha 11 is notably high in heart and uterus, with lower levels found in pancreas, kidney, skeletal muscle, placenta, lung, colon, and brain. Formation of heterodimers with Integrin β1 enhances Integrin alpha 11′s role in mediating cell adhesion and signaling, which is vital for tissue integrity and repair. Interaction of Integrin alpha 11 with collagen not only facilitates cellular attachment but also plays a significant role in various physiological processes, including wound healing and tissue remodeling, making Integrin alpha 11 an important target for research in developmental biology and disease pathology.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

Integrin α11/ITGA11 Antibody (F-5) References:

  1. cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues.  |  Velling, T., et al. 1999. J Biol Chem. 274: 25735-42. PMID: 10464311
  2. Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11).  |  Lehnert, K., et al. 1999. Genomics. 60: 179-87. PMID: 10486209
  3. alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells.  |  Tiger, CF., et al. 2001. Dev Biol. 237: 116-29. PMID: 11518510
  4. Analysis of the human integrin alpha11 gene (ITGA11) and its promoter.  |  Zhang, WM., et al. 2002. Matrix Biol. 21: 513-23. PMID: 12392762
  5. alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens.  |  Zhang, WM., et al. 2003. J Biol Chem. 278: 7270-7. PMID: 12496264
  6. Integrin alpha 11 is a novel type I interferon stimulated gene.  |  Leomil Coelho, LF., et al. 2006. Cytokine. 33: 352-61. PMID: 16697656
  7. Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells.  |  Zhu, CQ., et al. 2007. Proc Natl Acad Sci U S A. 104: 11754-9. PMID: 17600088
  8. Overexpression of integrin α11 induces cardiac fibrosis in mice.  |  Romaine, A., et al. 2018. Acta Physiol (Oxf). 222: PMID: 28771943
  9. Stromal integrin α11 regulates PDGFR-β signaling and promotes breast cancer progression.  |  Primac, I., et al. 2019. J Clin Invest. 129: 4609-4628. PMID: 31287804
  10. In situ antibody phage display yields optimal inhibitors of integrin α11/β1.  |  Gallo, E., et al. 2020. MAbs. 12: 1717265. PMID: 31980006
  11. Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis.  |  Martínez-Nieto, GA., et al. 2022. Front Oncol. 12: 981009. PMID: 36003785
  12. siRNA treatment targeting integrin α11 overexpressed via EZH2-driven axis inhibits drug-resistant breast cancer progression.  |  Chaudhary, P., et al. 2024. Breast Cancer Res. 26: 72. PMID: 38664825

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Integrin α11/ITGA11 Antibody (F-5)

sc-390091
200 µg/ml
$316.00

Integrin α11/ITGA11 Antibody (F-5): m-IgG Fc BP-HRP Bundle

sc-530058
200 µg Ab; 10 µg BP
$354.00

Integrin α11/ITGA11 Antibody (F-5): m-IgGκ BP-HRP Bundle

sc-523398
200 µg Ab, 40 µg BP
$354.00

Integrin α11/ITGA11 Antibody (F-5): m-IgG1 BP-HRP Bundle

sc-543846
200 µg Ab; 20 µg BP
$354.00

Integrin α11/ITGA11 Antibody (F-5) AC

sc-390091 AC
500 µg/ml, 25% agarose
$416.00

Integrin α11/ITGA11 Antibody (F-5) HRP

sc-390091 HRP
200 µg/ml
$316.00

Integrin α11/ITGA11 Antibody (F-5) FITC

sc-390091 FITC
200 µg/ml
$330.00

Integrin α11/ITGA11 Antibody (F-5) PE

sc-390091 PE
200 µg/ml
$343.00

Integrin α11/ITGA11 Antibody (F-5) Alexa Fluor® 488

sc-390091 AF488
200 µg/ml
$357.00

Integrin α11/ITGA11 Antibody (F-5) Alexa Fluor® 546

sc-390091 AF546
200 µg/ml
$357.00

Integrin α11/ITGA11 Antibody (F-5) Alexa Fluor® 594

sc-390091 AF594
200 µg/ml
$357.00

Integrin α11/ITGA11 Antibody (F-5) Alexa Fluor® 647

sc-390091 AF647
200 µg/ml
$357.00

Integrin α11/ITGA11 Antibody (F-5) Alexa Fluor® 680

sc-390091 AF680
200 µg/ml
$357.00

Integrin α11/ITGA11 Antibody (F-5) Alexa Fluor® 790

sc-390091 AF790
200 µg/ml
$357.00

Is this antibody only reactive to human samples? I need a conjugated antibody against ITGA11 that reacts with mouse samples and that is compatible with flow cytometry.

Asked by: Valentin
Thank you for your question. Based on our tests with the product, Integrin α11/ITGA11 Antibody (F-5) is only recommended for detection of Integrin α11 of human origin by WB, IP, IF and ELISA. We do not recommend it for use in any other species. We currently do not offer other antibodies specific against this particular target.
Answered by: Tech Support Europe
Date published: 2025-07-01

What is the recommended starting dilution for Western blot for sc-390091: Integrin α11 (F-5) monoclonal antibody?

Asked by: DefinitelyNotMatt
The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, is available in the recommended protocol: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-03-22
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Rated 5 out of 5 by from 一次性赠送了3支小样,大气。使用后实验效果好。值得推荐不久前买了此产品,一次性赠送了3支小样,大气。使用后实验效果好。值得推荐,服务非常完美。希望继续合作。如果有机会继续向客户推荐贵司产品。
Date published: 2022-07-16
Rated 3 out of 5 by from No bad.We used the ITGA11 antibody at 1/50 dilution in IF. The antibody detected in fibroblastic cells.
Date published: 2022-04-18
Rated 2 out of 5 by from Didn't work in IHCWe have tried a free sample of this antibody on human cryosections with acetone fixation and 1:100 diluition of the antibody. No signal was detected (we used another a11 antibody as positive control). A higher concentration of the antibody/longer incubation time could be considered to get a signal..
Date published: 2017-10-31
Rated 5 out of 5 by from good featureswe used this antibody to detect the expression of integrin in glioma cell lysate by western blot
Date published: 2017-08-14
Rated 5 out of 5 by from Clean blot with single strong band at expectedClean blot with single strong band at expected size using human uterus tissue extract. -SCBT QC
Date published: 2015-04-06
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Integrin α11/ITGA11 Antibody (F-5) is rated 4.0 out of 5 by 5.
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