INSR/Insulin Receptor β Antibody (C-4): sc-373975
- INSR/Insulin Receptor β Antibody (C-4) is a mouse monoclonal IgG2a κ, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 941-1010 of insulin Rβ of human origin
- Anti-INSR/Insulin Receptor β Antibody (C-4) is recommended for detection of insulin Rβ of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and porcine
- Anti-INSR/Insulin Receptor β Antibody (C-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for INSR/Insulin Receptor β Antibody (C-4) for WB applications. These reagents are now offered in bundles with INSR/Insulin Receptor β Antibody (C-4) (see ordering information below).
QUICK LINKS
Insulin Rβ Antibody (C-4) is a mouse monoclonal IgG2a kappa light chain antibody designed to target amino acids 941-1010 of the human insulin receptor β (INSR) subunit. anti-INSR β antibody (C-4) is an essential tool for researchers investigating insulin signaling pathways, effectively recognizing INSR β across multiple species, including mouse, rat, human, equine, canine, and porcine, and is suitable for various applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). The insulin receptor is a critical heterodimeric protein composed of α and β subunits, where the β subunit possesses intrinsic tyrosine kinase activity necessary for propagating insulin′s effects on glucose uptake and metabolism. Upon insulin binding, INSR undergoes autophosphorylation and recruits a cascade of interacting proteins, including insulin receptor substrates (IRS1 and IRS2), SHC (Src Homology 2 domain-containing), and the PI3K (phosphoinositide 3-kinase) complex, which play pivotal roles in downstream signaling pathways such as the MAPK/ERK and PI3K/Akt pathways. These interactions facilitate various cellular responses, including glucose transport, glycogen synthesis, and cell growth. INSR β monoclonal antibody (C-4) detection of phosphorylated forms of INSR β enables detailed studies of these interactions and activation status of the receptor, which is crucial for understanding molecular mechanisms underlying insulin resistance in type 2 diabetes and autoimmune destruction of insulin-producing cells in type 1 diabetes. Additionally, INSR β (C-4) antibody is available in multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing versatility for diverse experimental setups. By enabling precise detection and analysis of the insulin receptor and associated proteins, INSR β (C-4) monoclonal antibody serves as an indispensable reagent for advancing diabetes research and development of targeted therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
INSR/Insulin Receptor β Antibody (C-4) | sc-373975 | 200 µg/ml | $316.00 | |||
INSR/Insulin Receptor β Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-529625 | 200 µg Ab; 10 µg BP | $354.00 | |||
INSR/Insulin Receptor β Antibody (C-4): m-IgGκ BP-HRP Bundle | sc-522577 | 200 µg Ab, 40 µg BP | $354.00 | |||
INSR/Insulin Receptor β Antibody (C-4): m-IgG2a BP-HRP Bundle | sc-547343 | 200 µg Ab; 10 µg BP | $354.00 | |||
INSR/Insulin Receptor β Antibody (C-4) AC | sc-373975 AC | 500 µg/ml, 25% agarose | $416.00 | |||
INSR/Insulin Receptor β Antibody (C-4) HRP | sc-373975 HRP | 200 µg/ml | $316.00 | |||
INSR/Insulin Receptor β Antibody (C-4) FITC | sc-373975 FITC | 200 µg/ml | $330.00 | |||
INSR/Insulin Receptor β Antibody (C-4) PE | sc-373975 PE | 200 µg/ml | $343.00 | |||
INSR/Insulin Receptor β Antibody (C-4) Alexa Fluor® 488 | sc-373975 AF488 | 200 µg/ml | $357.00 | |||
INSR/Insulin Receptor β Antibody (C-4) Alexa Fluor® 546 | sc-373975 AF546 | 200 µg/ml | $357.00 | |||
INSR/Insulin Receptor β Antibody (C-4) Alexa Fluor® 594 | sc-373975 AF594 | 200 µg/ml | $357.00 | |||
INSR/Insulin Receptor β Antibody (C-4) Alexa Fluor® 647 | sc-373975 AF647 | 200 µg/ml | $357.00 | |||
INSR/Insulin Receptor β Antibody (C-4) Alexa Fluor® 680 | sc-373975 AF680 | 200 µg/ml | $357.00 | |||
INSR/Insulin Receptor β Antibody (C-4) Alexa Fluor® 790 | sc-373975 AF790 | 200 µg/ml | $357.00 |