INSR/Insulin Receptor β Antibody (9H4): sc-81466

Insulin Rβ Antibody (9H4) is a mouse monoclonal IgG1 antibody designed to target the activation loop of the human insulin receptor (IR) β subunit. Anti-insulin receptor β antibody (9H4) is essential for researchers studying the intricate signaling mechanisms of the insulin receptor, a critical player in glucose metabolism and energy homeostasis. The insulin receptor is a heterodimeric protein composed of α and β subunits, where the β subunit possesses intrinsic tyrosine kinase activity essential for signal transduction upon insulin binding. Post-translational modifications, particularly phosphorylation of the β subunit′s tyrosine residues, are pivotal for activating downstream signaling pathways that regulate glucose uptake and glycogen synthesis. Insulin receptor β monoclonal antibody (9H4) specifically recognizes these phosphorylated sites, enabling precise detection and analysis of the receptor′s activation state. Anti-insulin receptor β antibody (9H4) demonstrates robust reactivity across multiple species, including mouse, rat, human, and canine, making it versatile for various experimental applications such as western blotting (WB) and immunoprecipitation (IP). Understanding these post-translational modifications is crucial as they influence the receptor′s functionality and its role in conditions like type 1 and type 2 diabetes, where insulin signaling is disrupted. By facilitating the study of these modifications, insulin receptor β (9H4) antibody serves as an invaluable tool for advancing diabetes research and the development of therapeutic strategies.

The preferred INSR/Insulin Receptor β antibody is INSR/Insulin Receptor β Antibody (CT-3): sc-57342.