Influenza A Virus Hemagglutinin Antibody (C102): sc-52025

Influenza A Virus Hemagglutinin Antibody (C102) is a mouse monoclonal IgG1 kappa light chain antibody that detects Influenza A Virus Hemagglutinin protein by western blotting (WB) and immunofluorescence (IF). Anti-Influenza A Virus Hemagglutinin antibody (C102) is available as a non-conjugated format. Hemagglutinin (HA) is a critical glycoprotein located on the surface of the Influenza A virus, playing a vital role in viral infection of host cells. HA facilitates initial viral attachment by binding to sialic acid residues on respiratory tract epithelial cells. This binding triggers fusion of the viral envelope with the host cell membrane, allowing viral RNA entry and replication. HA′s crucial role in infection makes this protein a key target for vaccine development and therapeutic interventions, as understanding HA structure and function can lead to more effective strategies for preventing and treating influenza infections. Influenza A viruses are negative sense, single-stranded, segmented RNA viruses primarily hosted by birds, though capable of infecting various mammalian species. Influenza A subtype classification relies on hemagglutinin and neuraminidase glycoprotein combinations, with 16 known HA subtypes (H1-H16) and nine NA subtypes (N1-N9), demonstrating these viruses′ diversity and adaptability across different hosts.

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Influenza A Virus Hemagglutinin Antibody (C102) References:

1. Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin.  |  Skehel, JJ. and Wiley, DC. 2000. Annu Rev Biochem. 69: 531-69. PMID: 10966468
2. Early steps of the conformational change of influenza virus hemagglutinin to a fusion active state: stability and energetics of the hemagglutinin.  |  Huang, Q., et al. 2003. Biochim Biophys Acta. 1614: 3-13. PMID: 12873761
3. Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion.  |  Takeda, M., et al. 2003. Proc Natl Acad Sci U S A. 100: 14610-7. PMID: 14561897
4. Completion of trimeric hairpin formation of influenza virus hemagglutinin promotes fusion pore opening and enlargement.  |  Borrego-Diaz, E., et al. 2003. Virology. 316: 234-44. PMID: 14644606
5. Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization.  |  Lau, WL., et al. 2004. Biophys J. 86: 272-84. PMID: 14695269
6. Structural basis of immune recognition of influenza virus hemagglutinin.  |  Wilson, IA. and Cox, NJ. 1990. Annu Rev Immunol. 8: 737-71. PMID: 2188678
7. Influenza A Virus Hemagglutinin-Neuraminidase-Receptor Balance: Preserving Virus Motility.  |  de Vries, E., et al. 2020. Trends Microbiol. 28: 57-67. PMID: 31629602
8. Influenza virus A pathogenicity: the pivotal role of hemagglutinin.  |  Webster, RG. and Rott, R. 1987. Cell. 50: 665-6. PMID: 3304656
9. Influenza A Virus Hemagglutinin and Other Pathogen Glycoprotein Interactions with NK Cell Natural Cytotoxicity Receptors NKp46, NKp44, and NKp30.  |  Luczo, JM., et al. 2021. Viruses. 13: PMID: 33494528
10. Influenza A virus hemagglutinin prevents extensive membrane damage upon dehydration.  |  Iriarte-Alonso, MA., et al. 2022. BBA Adv. 2: 100048. PMID: 37082591
11. Expression of wild-type and mutant forms of influenza hemagglutinin: the role of folding in intracellular transport.  |  Gething, MJ., et al. 1986. Cell. 46: 939-50. PMID: 3757030
12. Immunogenic structure of the influenza virus hemagglutinin.  |  Green, N., et al. 1982. Cell. 28: 477-87. PMID: 6176330

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Influenza A Virus Hemagglutinin Antibody (C102) has 19 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Influenza A Virus Hemagglutinin Antibody (C102) Specifications

Alternate Product Name: Influenza A Virus Haemagglutinin

Product Clone Name: C102

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Influenza A Virus Hemagglutinin

Epitope Species: Influenza A Virus

Product Reactivity/Detection: hemagglutinin of H1N1 serotype

Species Reactivity/Detection: Influenza A Virus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 19 citations in various scientific publications

Available Conjugates/Forms for Influenza A Virus Hemagglutinin Antibody (C102): N/A