INDOL1 Antibody (C-9): sc-374159
- INDOL1 Antibody (C-9) is a mouse monoclonal IgG2a κ INDOL1 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 261-370 mapping near the C-terminus of INDOL1 of mouse origin
- INDOL1 Antibody (C-9) is recommended for detection of INDOL1 of mouse origin by WB, IP, IF and ELISA
- Anti-INDOL1 Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for INDOL1 Antibody (C-9) for WB applications. These reagents are now offered in bundles with INDOL1 Antibody (C-9) (see ordering information below).
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INDOL1 Antibody (C-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects INDOL1 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-INDOL1 antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. INDOL1, also known as indoleamine 2,3-dioxygenase-like protein 1 or IDO2, plays a crucial role in the kynurenine pathway of tryptophan metabolism, catalyzing the first step in this pathway. This pathway leads to the production of several metabolites involved in various physiological and pathological processes, including immune response modulation. INDOL1 is expressed in a variety of tissues such as the liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, colon, and dendritic cells, highlighting its importance in diverse biological functions. Notably, INDOL1 is selectively inhibited by D-1MT (1-methyl-d-tryptophan), which also inhibits IDO, suggesting a shared role in immunomodulation, particularly in the context of tumor immunity where IDO expression can suppress T cell responses. Additionally, variations in the human INDOL1 gene, specifically two single nucleotide polymorphisms, have been identified that abolish its enzymatic function, further emphasizing INDOL1′s relevance in immunological research and potential therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
INDOL1 Antibody (C-9) References:
- Fuel feeds function: energy metabolism and the T-cell response. | Fox, CJ., et al. 2005. Nat Rev Immunol. 5: 844-52. PMID: 16239903
- The human indoleamine 2,3-dioxygenase gene and related human genes. | Murray, MF. 2007. Curr Drug Metab. 8: 197-200. PMID: 17430106
- Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. | Ball, HJ., et al. 2007. Gene. 396: 203-13. PMID: 17499941
- Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. | Metz, R., et al. 2007. Cancer Res. 67: 7082-7. PMID: 17671174
- Is IDO a key enzyme bridging the gap between tumor escape and tolerance induction? | Löb, S. and Königsrainer, A. 2008. Langenbecks Arch Surg. 393: 995-1003. PMID: 18064486
- Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway. | Ball, HJ., et al. 2009. Int J Biochem Cell Biol. 41: 467-71. PMID: 18282734
- Immune escape as a fundamental trait of cancer: focus on IDO. | Prendergast, GC. 2008. Oncogene. 27: 3889-900. PMID: 18317452
- Brain serotonin content: physiological dependence on plasma tryptophan levels. | Fernstrom, JD. and Wurtman, RJ. 1971. Science. 173: 149-52. PMID: 5581909
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
INDOL1 Antibody (C-9) | sc-374159 | 200 µg/ml | $316.00 | |||
INDOL1 Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-529677 | 200 µg Ab; 10 µg BP | $354.00 | |||
INDOL1 Antibody (C-9): m-IgGκ BP-HRP Bundle | sc-522644 | 200 µg Ab, 40 µg BP | $354.00 | |||
INDOL1 Antibody (C-9): m-IgG2a BP-HRP Bundle | sc-547361 | 200 µg Ab; 10 µg BP | $354.00 | |||
INDOL1 Antibody (C-9) AC | sc-374159 AC | 500 µg/ml, 25% agarose | $416.00 | |||
INDOL1 Antibody (C-9) HRP | sc-374159 HRP | 200 µg/ml | $316.00 | |||
INDOL1 Antibody (C-9) FITC | sc-374159 FITC | 200 µg/ml | $330.00 | |||
INDOL1 Antibody (C-9) PE | sc-374159 PE | 200 µg/ml | $343.00 | |||
INDOL1 Antibody (C-9) Alexa Fluor® 488 | sc-374159 AF488 | 200 µg/ml | $357.00 | |||
INDOL1 Antibody (C-9) Alexa Fluor® 546 | sc-374159 AF546 | 200 µg/ml | $357.00 | |||
INDOL1 Antibody (C-9) Alexa Fluor® 594 | sc-374159 AF594 | 200 µg/ml | $357.00 | |||
INDOL1 Antibody (C-9) Alexa Fluor® 647 | sc-374159 AF647 | 200 µg/ml | $357.00 | |||
INDOL1 Antibody (C-9) Alexa Fluor® 680 | sc-374159 AF680 | 200 µg/ml | $357.00 | |||
INDOL1 Antibody (C-9) Alexa Fluor® 790 | sc-374159 AF790 | 200 µg/ml | $357.00 |