Importin-7 Antibody (H-12): sc-271701
- Importin-7 Antibody (H-12) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 961-1038 mapping at the C-terminus of Importin-7 of human origin
- recommended for detection of Importin-7 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Importin-7 Antibody (H-12) for WB applications. These reagents are now offered in bundles with Importin-7 Antibody (H-12) (see ordering information below).
QUICK LINKS
Importin-7 Antibody (H-12) is a mouse monoclonal IgG1 antibody that detects Importin-7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Importin-7, also known as Ran-binding protein 7 or RanBP7, is a crucial 1,038 amino acid protein encoded by the human gene IPO7, belonging to the importin β family and characterized by its single importin N-terminal domain. Anti-Importin-7 antibody (H-12) plays a vital role in studying nuclear protein import, where Importin-7 functions either as an independent nuclear transport receptor or as an adapter-like protein in conjunction with the Importin β subunit KPNB1. Importin-7 serves as a receptor for nuclear localization signals (NLS), facilitating the translocation of import substrates through the nuclear pore complex (NPC) via an energy-dependent, Ran-mediated mechanism. Upon reaching the nucleoplasmic side of the NPC, Importin-7 binds to Ran, leading to the dissociation of the Importin-7/substrate complex, after which Importin-7 is re-exported to the cytoplasm, where GTP hydrolysis releases Ran. Importin-7 is predominantly expressed in the nucleus and is found in most tissues, underscoring its essential role in cellular function and regulation. Importin-7 monoclonal antibody (H-12) is an invaluable tool for researchers studying nuclear transport mechanisms and the intricate processes of cellular signaling.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Importin-7 Antibody (H-12) | sc-271701 | 200 µg/ml | $322.00 | |||
Importin-7 Antibody (H-12): m-IgG Fc BP-HRP Bundle | sc-537684 | 200 µg Ab; 10 µg BP | $361.00 | |||
Importin-7 Antibody (H-12): m-IgGκ BP-HRP Bundle | sc-535028 | 200 µg Ab; 40 µg BP | $361.00 | |||
Importin-7 Antibody (H-12): m-IgG1 BP-HRP Bundle | sc-545305 | 200 µg Ab; 20 µg BP | $361.00 |