IMPA1 Antibody (H-7): sc-374234
- IMPA1 Antibody (H-7) is a mouse monoclonal IgG1 κ IMPA1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-85 mapping at the N-terminus of IMPA1 of human origin
- IMPA1 Antibody (H-7) is recommended for detection of IMPA1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-IMPA1 Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IMPA1 Antibody (H-7) for WB and IHC(P) applications. These reagents are now offered in bundles with IMPA1 Antibody (H-7) (see ordering information below).
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IMPA1 Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects IMPA1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). IMPA1 (H-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IMPA1 protein, also known as Myo-inositol monophosphatase 1, plays a crucial role in the procurement of inositol, which is essential for the synthesis of phosphatidylinositol and polyphosphoinositides, key components in cellular signaling pathways. Located primarily in the cytoplasm, IMPA1 exists as a homodimer and serves as the principal enzyme in the phosphatidylinositol signaling pathway, making IMPA1 a significant pharmacological target for lithium action in the brain. The inhibition of inositol monophosphatase hydrolysis is believed to underlie the anti-manic and anti-depressant effects of lithium, highlighting IMPA1′s importance in mood regulation. Studies have shown that variations in the 277 codon of the IMPA1 gene are not present in manic-depressive patients, suggesting that polymorphisms or mutations in the noncoding regions of this gene may influence the lithium response in psychiatric conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IMPA1 Antibody (H-7) References:
- Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop. | Stieglitz, KA., et al. 2002. J Biol Chem. 277: 22863-74. PMID: 11940584
- Regional changes in rat brain inositol monophosphatase 1 (IMPase 1) activity with chronic lithium treatment. | Parthasarathy, LK., et al. 2003. Prog Neuropsychopharmacol Biol Psychiatry. 27: 55-60. PMID: 12551726
- cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme. | McAllister, G., et al. 1992. Biochem J. 284 (Pt 3): 749-54. PMID: 1377913
- Chemistry and biology of deoxy-myo-inositol phosphates: stereospecificity of substrate interactions within an archaeal and a bacterial IMPase. | Morgan, AJ., et al. 2004. J Am Chem Soc. 126: 15370-1. PMID: 15563150
- A molecular mechanism for the effect of lithium on development. | Klein, PS. and Melton, DA. 1996. Proc Natl Acad Sci U S A. 93: 8455-9. PMID: 8710892
- Lack of genetic variation in the coding region of the myo-inositol monophosphatase gene in lithium-treated patients with manic depressive illness. | Steen, VM., et al. 1996. Pharmacogenetics. 6: 113-6. PMID: 8845858
- Genomic structure and chromosomal localization of a human myo-inositol monophosphatase gene (IMPA). | Sjøholt, G., et al. 1997. Genomics. 45: 113-22. PMID: 9339367
- Effect of the IMPase inhibitor L690,330 on sea urchin development. | Sconzo, G., et al. 1998. Cell Biol Int. 22: 91-4. PMID: 9878095
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IMPA1 Antibody (H-7) | sc-374234 | 200 µg/ml | $316.00 | |||
IMPA1 Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-529695 | 200 µg Ab; 10 µg BP | $354.00 | |||
IMPA1 Antibody (H-7): m-IgGκ BP-HRP Bundle | sc-522669 | 200 µg Ab, 40 µg BP | $354.00 | |||
IMPA1 Antibody (H-7): m-IgG1 BP-HRP Bundle | sc-543639 | 200 µg Ab; 20 µg BP | $354.00 | |||
IMPA1 Antibody (H-7) AC | sc-374234 AC | 500 µg/ml, 25% agarose | $416.00 | |||
IMPA1 Antibody (H-7) HRP | sc-374234 HRP | 200 µg/ml | $316.00 | |||
IMPA1 Antibody (H-7) FITC | sc-374234 FITC | 200 µg/ml | $330.00 | |||
IMPA1 Antibody (H-7) PE | sc-374234 PE | 200 µg/ml | $343.00 | |||
IMPA1 Antibody (H-7) Alexa Fluor® 488 | sc-374234 AF488 | 200 µg/ml | $357.00 | |||
IMPA1 Antibody (H-7) Alexa Fluor® 546 | sc-374234 AF546 | 200 µg/ml | $357.00 | |||
IMPA1 Antibody (H-7) Alexa Fluor® 594 | sc-374234 AF594 | 200 µg/ml | $357.00 | |||
IMPA1 Antibody (H-7) Alexa Fluor® 647 | sc-374234 AF647 | 200 µg/ml | $357.00 | |||
IMPA1 Antibody (H-7) Alexa Fluor® 680 | sc-374234 AF680 | 200 µg/ml | $357.00 | |||
IMPA1 Antibody (H-7) Alexa Fluor® 790 | sc-374234 AF790 | 200 µg/ml | $357.00 |