IMPA1 Antibody (A-2): sc-373733

IMPA1 Antibody (A-2) is a mouse monoclonal IgG2a antibody that detects IMPA1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IMPA1, also known as Myo-inositol monophosphatase 1, plays a crucial role in the procurement of inositol, which is essential for the synthesis of phosphatidylinositol and polyphosphoinositides, key components in cellular signaling pathways. IMPA1 exists as a homodimer and serves as the principal enzyme in the phosphatidylinositol signaling pathway, making IMPA1 a significant pharmacological target for lithium action in the brain. The inhibition of inositol monophosphatase hydrolysis is believed to underlie the therapeutic effects of lithium in treating mood disorders, including its anti-manic and anti-depressant properties. Notably, research has shown that variations in the 277 codon of the IMPA1 gene are not present in manic-depressive patients, suggesting that polymorphisms or mutations in the noncoding regions of this gene may play a role in influencing the lithium response among psychiatric patients. Anti-IMPA1 antibody (A-2) is an invaluable tool for researchers investigating the molecular mechanisms underlying mood regulation and the effects of lithium therapy.

The preferred IMPA1 antibody is IMPA1 Antibody (H-7): sc-374234.