IL-8 Antibody (A-6): sc-7302

IL-8 Antibody (A-6) is a mouse monoclonal IgG1 antibody that detects IL-8 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IL-8 is a crucial chemokine that plays a significant role in the immune response by acting as a chemoattractant for neutrophils, which are essential for combating infections and mediating inflammation. IL-8 is secreted by various cell types, including macrophages and epithelial cells, and expression is often upregulated in response to pro-inflammatory stimuli. This localization and regulation are vital, as elevated levels of IL-8 have been implicated in numerous chronic inflammatory diseases, such as inflammatory bowel disease and atherosclerosis. IL-8 is produced as a 99 amino acid precursor that is cleaved to yield a biologically active 72 amino acid form, which can exist as monomers or dimers. The dimerization of IL-8 is particularly important as IL-8 serves as a negative regulator of IL-8 receptor function, impacting the signaling pathways that govern neutrophil chemotaxis. The two known receptors for IL-8, IL-8RA and IL-8RB, share a high degree of sequence identity and are structurally similar to G protein-coupled receptors, further underscoring the complexity of IL-8′s role in immune regulation. With an ability to modulate inflammatory responses, IL-8 is a critical target for research into therapeutic interventions for various inflammatory conditions, making IL-8 (A-6) antibody an invaluable tool for scientists studying these pathways.

The preferred IL-8 antibody is IL-8 Antibody (C-11): sc-376750.