IL-8 Activators
Common IL-8 Activators include, but are not limited to Lipopolysaccharide, E. coli O55:B5 CAS 93572-42-0, Thapsigargin CAS 67526-95-8, Hydrogen Peroxide CAS 7722-84-1, PMA CAS 16561-29-8 and Dexamethasone CAS 50-02-2.
Interleukin-8 (IL-8) is a potent chemokine primarily known for its role in the innate immune response. Chemokines, a subset of cytokines, are small secreted proteins that guide the migration of immune cells, and IL-8 is particularly effective in attracting neutrophils to sites of infection or injury. Produced by various cell types, including macrophages, epithelial cells, and endothelial cells, IL-8 is released in response to inflammatory signals. It functions by binding to specific receptors on the surface of target cells, primarily CXCR1 and CXCR2, initiating a cascade of intracellular events that direct cell movement. Beyond chemotaxis, IL-8 also plays a role in angiogenesis and the proliferation of certain cell types. Given its diverse functions, IL-8 is integral to the orchestration of inflammatory responses, ensuring that immune cells are promptly recruited to sites requiring defense or repair.
Activators of IL-8 are molecules or compounds that enhance the synthesis, release, or activity of IL-8. These activators might function by promoting IL-8 transcription, by stabilizing the IL-8 protein, or by amplifying its interaction with its receptors. The presence of IL-8 activators can lead to an increased chemotactic response, intensifying the recruitment of neutrophils and other immune cells to specific sites. Delving into the world of IL-8 activators provides a comprehensive understanding of the molecular mechanisms underpinning immune cell migration and inflammatory responses. As research continues to unravel the complex interplay of signals that govern immunity and inflammation, the role of IL-8 and its activators takes center stage, illuminating the intricate pathways that ensure an effective response to physiological challenges.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS activates the NF-κB pathway, which is a primary pathway for IL-8 transcriptional activation. LPS is a common stimulator for IL-8 in many cell types, especially in macrophages and endothelial cells. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
This compound induces ER stress and can lead to increased IL-8 expression. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Induces oxidative stress, which can increase IL-8 expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates PKC, which can lead to activation of the NF-κB pathway and subsequent upregulation of IL-8. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
While dexamethasone often suppresses cytokine production, in certain conditions, it might induce IL-8 expression. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
This immunosuppressant suggested compound that may induce IL-8 expression in certain cell types. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Directly activates JNK/p38 MAPKs phosphorylating c-Jun and ATF2 which bind AP-1 sites on IL-8 locus. | ||||||
Nickel Sulfate | 7786-81-4 | sc-507407 | 5 g | $63.00 | ||
Heavy metal activates multiple transcription factors like NF-κB involved in IL-8 transcriptional regulation. | ||||||