IL-8 Antibody (3E4D8): sc-32817

IL-8 Antibody (3E4D8) is a mouse monoclonal IgG1 antibody that detects interleukin-8 (IL-8) in human samples through western blotting (WB) and immunoprecipitation (IP) applications. IL-8 is a crucial chemokine that plays a significant role in the immune response by acting as a chemoattractant for neutrophils, thereby facilitating their migration to sites of inflammation. This function is particularly important in the context of chronic inflammatory diseases, such as inflammatory bowel disease and atherosclerosis, where IL-8 levels are often elevated. The protein is initially synthesized as a 99 amino acid precursor, which is then cleaved to produce a biologically active 72 amino acid form. IL-8 exists in both monomeric and dimeric forms, with dimerization serving as a negative regulator of IL-8 receptor function, which is essential for modulating the immune response. The receptors for IL-8, IL-8RA and IL-8RB, are seven-transmembrane domain proteins that share a high degree of sequence identity and are also involved in the signaling of other chemokines. Anti-IL-8 antibody (3E4D8) is an invaluable tool for researchers studying the complex roles of IL-8 in inflammation and immune regulation.

The preferred IL-8 antibody is IL-8 Antibody (C-11): sc-376750.