IL-4 Antibody (11B11): sc-32242
- IL-4 Antibody (11B11) is a rat monoclonal IgG1, cited in 6 publications, provided at 200 µg/ml
- raised against partially purified IL-4 of mouse origin
- recommended for detection of IL-4 of mouse origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for neutralization, sc-32242 L, 200 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-4 Antibody (11B11). This work is in progress.
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IL-4 Antibody (11B11) is a rat monoclonal IgG1 antibody that detects interleukin-4 (IL-4) in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). IL-4 is a crucial glycosylated cytokine secreted by activated T lymphocytes, basophils, and mast cells, playing a significant role in the immune response by promoting the growth and differentiation of immune cells. One of the key functions of IL-4 is inducing immunoglobulin class switching, which is vital for the adaptive immune system′s effectiveness. Specifically, IL-4 stimulates B cells to produce immunoglobulin E (IgE) and enhances the secretion of immunoglobulin G4 (IgG4), while simultaneously suppressing the production of other immunoglobulin classes such as IgM, IgA, IgG1, IgG2, and IgG3. This selective regulation of immunoglobulin production is essential for mounting appropriate immune responses, particularly in allergic reactions and responses to parasitic infections. Furthermore, the signaling pathway activated by IL-4 involves the rapid tyrosine phosphorylation of Stat6, a transcription factor that mediates the effects of IL-4 on gene expression, underscoring the importance of IL-4 in orchestrating immune responses. Anti-IL-4 antibody (11B11) serves as an invaluable tool for researchers studying the complex roles of cytokines in immune regulation and disease.
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IL-4 Antibody (11B11) References:
- Spatial regulation of IL-4 signalling in vivo. | Redpath, SA., et al. 2015. Cytokine. 75: 51-6. PMID: 25819429
- Regulation of IL-4 Expression in Immunity and Diseases. | Ho, IC. and Miaw, SC. 2016. Adv Exp Med Biol. 941: 31-77. PMID: 27734408
- IL-4 up-regulates cyclooxygenase-1 expression in macrophages. | Shay, AE., et al. 2017. J Biol Chem. 292: 14544-14555. PMID: 28684424
- Analysis of IL-4/STAT6 Signaling in Macrophages. | Waqas, SFH., et al. 2019. Methods Mol Biol. 1966: 211-224. PMID: 31041750
- IL-4 absence triggers distinct pathways in apical periodontitis development. | Freire, MS., et al. 2021. J Proteomics. 233: 104080. PMID: 33338687
- Basophils balance healing after myocardial infarction via IL-4/IL-13. | Sicklinger, F., et al. 2021. J Clin Invest. 131: PMID: 34196299
- Staphylococcal γ-hemolysins induce IL-4 production in murine basophils. | Ogata, A., et al. 2022. Biochem Biophys Res Commun. 632: 107-112. PMID: 36206594
- The value of serum IL-4 to predict the survival of MDS patients. | Liu, Z., et al. 2023. Eur J Med Res. 28: 7. PMID: 36600245
- IL-4 drastically decreases deuterosomal and multiciliated cells via alteration in progenitor cell differentiation. | Cho, HJ., et al. 2023. Allergy. 78: 1866-1877. PMID: 36883528
- IL-4/IL-4 Ab complex enhances the accumulation of both antigen-specific and bystander CD8 T cells in mouse lungs infected with influenza A virus. | Park, HJ., et al. 2023. Lab Anim Res. 39: 32. PMID: 38037190
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-4 Antibody (11B11) | sc-32242 | 200 µg/ml | $316.00 | |||
IL-4 Antibody (11B11) FITC | sc-32242 FITC | 200 µg/ml | $330.00 | |||
IL-4 Antibody (11B11) L | sc-32242 L | 200 µg/0.1 ml | $316.00 | |||
IL-4 Antibody (11B11) PE | sc-32242 PE | 200 µg/ml | $343.00 |