IL-3 Antibody (G-11): sc-398210

IL-3 Antibody (G-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects IL-3 of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-3 Antibody (G-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Interleukin-3, or IL-3, is a crucial pleiotropic cytokine primarily secreted by activated T lymphocytes, playing a vital role in the proliferation and differentiation of hematopoietic cells. IL-3 (G-11) antibody supports the growth of pluripotent stem cells and committed progenitors, essential for maintaining a healthy immune system, while also stimulating the functional activity of fully differentiated cells. IL-3 protects mast cells from apoptosis, ensuring their survival and functionality in immune responses. IL-3 (G-11) monoclonal antibody biological effects are mediated through a receptor comprising a ligand-specific α subunit and a common β subunit shared with IL-5 and granulocyte-macrophage colony-stimulating factor receptors. The β subunit′s carboxy terminus activates the MAP kinase signaling pathway, essential for various cellular responses. Although anti-IL-3 antibody (G-11) receptor lacks intrinsic kinase activity, stimulation leads to tyrosine phosphorylation of JAK2, a JAK/Tyk 2 family member, which activates and promotes nuclear translocation of Stat5a and Stat5b, further underscoring IL-3′s importance in hematopoietic regulation and immune function.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-3 Antibody (G-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-3 Antibody (G-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-3 Antibody (G-11) Specifications

Alternate Product Name: IL-3

Product Clone Name: G-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 137-156

Epitope Target: IL-3

Epitope Species: mouse

Product Reactivity/Detection: IL-3

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for IL-3 Antibody (G-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred IL-3 antibody is IL-3 Antibody (G-1): sc-28342.