IL-2Rβ Antibody (C-6): sc-393362

IL-2Rβ Antibody (C-6) is a mouse monoclonal IgG1 antibody that detects IL-2Rβ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-2Rβ, a critical component of the interleukin-2 receptor complex, plays a vital role in the immune response by mediating the signaling pathways that promote T cell proliferation and differentiation. IL-2Rβ is primarily located on the surface of T cells, where IL-2Rβ forms a high-affinity receptor complex with the α and γ chains, facilitating the binding of interleukin-2 (IL-2). IL-2Rβ is essential for the activation of T cells, which are crucial for adaptive immunity, and IL-2Rβ dysregulation can lead to immune disorders or impaired immune responses. Additionally, IL-2Rβ is involved in the formation of the IL-4 and IL-7 receptors, highlighting IL-2Rβ importance in various cytokine signaling pathways. Anti-IL-2Rβ antibody (C-6) is an invaluable tool for researchers studying T cell biology and the mechanisms of immune regulation, providing insights into potential therapeutic targets for immune-related diseases.

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IL-2Rβ Antibody (C-6) References:

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2. Induction of interleukin-2 receptor alpha (IL-2Ralpha) expression by interleukin-2: important role of the interleukin-2 receptor beta chain region between the two Stat5 docking sites.  |  Imbert, V., et al. 2002. Eur Cytokine Netw. 13: 331-9. PMID: 12231477
3. c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain.  |  Hatakeyama, M., et al. 1992. Proc Natl Acad Sci U S A. 89: 2022-6. PMID: 1549560
4. FK506 lacks the ability to inhibit expression of interleukin-2 receptor beta-chain on human lymphocytes.  |  Karlsson, H. and Nässberger, L. 1991. J Clin Lab Immunol. 36: 45-7. PMID: 1726895
5. Murine interleukin 2 receptor beta chain: dysregulated gene expression in lymphoma line EL-4 caused by a promoter insertion.  |  Kono, T., et al. 1990. Proc Natl Acad Sci U S A. 87: 1806-10. PMID: 2155425
6. Data on interleukin (IL)-2- and IL-15-dependent changes in IL-2Rβ and IL-2Rγ complexes.  |  Osinalde, N., et al. 2017. Data Brief. 11: 499-506. PMID: 28331895
7. Characterisation of IL-15 and IL-2Rβ in grass carp: IL-15 upregulates cytokines and transcription factors of type 1 immune response and NK cell activation.  |  Wang, W., et al. 2020. Fish Shellfish Immunol. 107: 104-117. PMID: 32971272
8. Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice.  |  Tanaka, T., et al. 1993. J Exp Med. 178: 1103-7. PMID: 8350049
9. Identification and cellular distribution of the rat interleukin-2 receptor beta chain: induction of the IL-2R alpha- beta+ phenotype by major histocompatibility complex class I recognition during T cell development in vivo and by T cell receptor stimulation of CD4+8+ immature thymocytes in vitro.  |  Park, JH., et al. 1996. Eur J Immunol. 26: 2371-5. PMID: 8898947
10. Genes for interleukin-2 receptor beta chain, interleukin-1 beta, and schizophrenia: no evidence for the association or linkage.  |  Tatsumi, M., et al. 1997. Am J Med Genet. 74: 338-41. PMID: 9184320

The preferred IL-2Rβ antibody is IL-2Rβ Antibody (C-2): sc-166427.