IL-2Rβ Antibody (C-2): sc-166427

IL-2Rβ Antibody (C-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects IL-2R beta protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-IL-2Rβ antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-2 receptor is a critical multicomponent complex composed of three subunits: alpha, beta, and gamma, which are essential for high-affinity binding of interleukin-2 (IL-2). Alpha chain primarily binds IL-2, while beta and gamma chains are crucial for IL-2 binding and subsequent activation of signaling pathways that promote T cell growth and differentiation. Common gamma chain, also known as γc, is not only a component of IL-2 receptor but also plays a significant role in functionality of other cytokine receptors, such as IL-4R and IL-7R, enhancing ligand binding capabilities. This intricate interplay underscores importance of IL-2 receptor in immune responses, making IL-2Rβ monoclonal antibody (C-2) a valuable tool for researchers studying T cell biology and cytokine signaling pathways.

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IL-2Rβ Antibody (C-2) References:

1. A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells.  |  Tanaka, T., et al. 1991. J Immunol. 147: 2222-8. PMID: 1918958
2. Interleukin-2 receptor beta-chain (p70-75) expressed on leukemic cells from adult T cell leukemia patients.  |  Kodaka, T., et al. 1990. Jpn J Cancer Res. 81: 902-8. PMID: 2121691
3. Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.  |  Hatakeyama, M., et al. 1989. Science. 244: 551-6. PMID: 2785715
4. The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms.  |  Mosley, B., et al. 1989. Cell. 59: 335-48. PMID: 2805066
5. Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor.  |  He, YW., et al. 1995. J Immunol. 154: 1596-605. PMID: 7530740
6. Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits.  |  Malek, TR., et al. 1995. J Interferon Cytokine Res. 15: 447-54. PMID: 7648447
7. Induction of interleukin 2 receptor beta chain expression by self-recognition in the thymus.  |  Hanke, T., et al. 1994. J Exp Med. 180: 1629-36. PMID: 7964450
8. Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4.  |  Kondo, M., et al. 1993. Science. 262: 1874-7. PMID: 8266076
9. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor.  |  Russell, SM., et al. 1993. Science. 262: 1880-3. PMID: 8266078
10. Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.  |  Cao, X., et al. 1993. Proc Natl Acad Sci U S A. 90: 8464-8. PMID: 8378320
11. The IL-2/IL-2 receptor system: a current overview.  |  Taniguchi, T. and Minami, Y. 1993. Cell. 73: 5-8. PMID: 8462103
12. The IL-2 receptor complex: its structure, function, and target genes.  |  Minami, Y., et al. 1993. Annu Rev Immunol. 11: 245-68. PMID: 8476561

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-2Rβ Antibody (C-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-2Rβ Antibody (C-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-2Rβ Antibody (C-2) Specifications

Alternate Product Name: IL-2Rβ

Product Clone Name: C-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 502-533

Epitope Target: IL-2Rβ

Epitope Species: human

Product Reactivity/Detection: IL-2Rβ

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for IL-2Rβ Antibody (C-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin