IL-2Rβ Antibody (C-10): sc-393093

IL-2Rβ Antibody (C-10) is a mouse monoclonal IgG2b kappa light chain antibody that detects IL-2Rβ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-IL-2Rβ antibody (C-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-2 receptor is a crucial multicomponent complex composed of three subunits: α, β, and γ, which are essential for high-affinity binding of interleukin-2 (IL-2). The α chain primarily binds IL-2, while the β and γ chains are vital for both IL-2 binding and the activation of signaling pathways that promote T cell proliferation. The common γ chain, also known as γc, is not only a component of IL-2 receptor but also plays a significant role in the functionality of other cytokine receptors, such as IL-4R and IL-7R, enhancing their ligand binding capabilities. This intricate interplay underscores IL-2Rβ′s importance in immune responses and highlights IL-2Rβ′s potential as a therapeutic target in various immunological disorders.

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IL-2Rβ Antibody (C-10) References:

1. Synthetic peptides as putative therapeutic agents in transplantation medicine: application of PEPSCAN to the identification of functional sequences in the extracellular domain of the interleukin-2 receptor beta chain (IL-2Rbeta).  |  Dionyssopoulou, H., et al. 2000. J Immunol Methods. 241: 83-95. PMID: 10915851
2. Decreased interleukin-2 receptor beta chain expression by peripheral blood lymphocytes in chronic liver disease.  |  Masumoto, T., et al. 1992. J Gastroenterol Hepatol. 7: 399-404. PMID: 1325198
3. Ultrastructural study of uterine natural killer cells found in pregnant, interleukin-2 receptor beta-chain overexpressed transgenic mice.  |  Kokubu, K., et al. 2005. J Reprod Dev. 51: 695-8. PMID: 16127247
4. Role of interleukin 2 receptor beta chain in initiating anti-CD3 and interleukin 2-induced proliferation of human resting T cells.  |  Moiré, N., et al. 1990. Eur J Immunol. 20: 1981-7. PMID: 2145171
5. Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences.  |  Gnarra, JR., et al. 1990. Proc Natl Acad Sci U S A. 87: 3440-4. PMID: 2333293
6. An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma.  |  Aspuria, PJ., et al. 2021. Sci Transl Med. 13: eabg7565. PMID: 34936383
7. Selection of internalization-deficient cells by interleukin-2-Pseudomonas exotoxin chimeric protein: the cytoplasmic domain of the interleukin-2 receptor beta chain does not contribute to internalization of interleukin-2.  |  Furse, RK. and Malek, TR. 1993. Eur J Immunol. 23: 3181-8. PMID: 8258333
8. Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.  |  Friedmann, MC., et al. 1996. Proc Natl Acad Sci U S A. 93: 2077-82. PMID: 8700888
9. An alpha-helical signal in the cytosolic domain of the interleukin 2 receptor beta chain mediates sorting towards degradation after endocytosis.  |  Subtil, A., et al. 1997. J Cell Biol. 136: 583-95. PMID: 9024689
10. Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation.  |  Migone, TS., et al. 1998. Mol Cell Biol. 18: 6416-22. PMID: 9774657

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-2Rβ Antibody (C-10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-2Rβ Antibody (C-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-2Rβ Antibody (C-10) Specifications

Alternate Product Name: IL-2Rβ

Product Clone Name: C-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 502-522

Epitope Target: IL-2Rβ

Epitope Species: mouse

Product Reactivity/Detection: IL-2Rβ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for IL-2Rβ Antibody (C-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred IL-2Rβ antibody is IL-2Rβ Antibody (C-2): sc-166427.