IL-17R Antibody (C-12): sc-515358

IL-17R Antibody (C-12) is a mouse monoclonal IgG2a antibody that detects IL-17R in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-IL-17R antibody (C-12) specifically targets IL-17 receptor, a type I transmembrane protein composed of 864 amino acids, which plays a crucial role in mediating the effects of the pro-inflammatory cytokine IL-17. IL-17R (C-12) antibody recognizes a receptor predominantly expressed in the spleen and kidney, highlighting its importance in immune responses and tissue homeostasis. The interaction between IL-17 and IL-17R is vital for the activation of downstream signaling pathways that lead to the production of other inflammatory cytokines, such as IL-6 and IL-8, thereby amplifying the immune response. Understanding the function and signaling mechanisms of IL-17R is essential for elucidating its role in various inflammatory diseases and conditions, making IL-17R (C-12) monoclonal antibody a valuable tool for researchers studying immune regulation and cytokine signaling pathways.

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IL-17R Antibody (C-12) References:

1. The activation and regulation of IL-17 receptor mediated signaling.  |  Song, X. and Qian, Y. 2013. Cytokine. 62: 175-82. PMID: 23557798
2. A Review of Brodalumab, an IL-17 Receptor Antagonist, for Moderate-to-Severe Plaque Psoriasis.  |  Tong, Y., et al. 2017. Skin Therapy Lett. 22: 1-6. PMID: 28122092
3. Activation of IL-17 receptor leads to increased oxidative inflammation in peripheral monocytes of autistic children.  |  Nadeem, A., et al. 2018. Brain Behav Immun. 67: 335-344. PMID: 28935156
4. The IL-17B-IL-17 receptor B pathway promotes resistance to paclitaxel in breast tumors through activation of the ERK1/2 pathway.  |  Laprevotte, E., et al. 2017. Oncotarget. 8: 113360-113372. PMID: 29371916
5. IL-17 Receptor Signaling Negatively Regulates the Development of Tubulointerstitial Fibrosis in the Kidney.  |  Ramani, K., et al. 2018. Mediators Inflamm. 2018: 5103672. PMID: 30405320
6. The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma.  |  Vella, G., et al. 2020. Respir Res. 21: 176. PMID: 32641167
7. IL-17 Receptor Signaling through IL-17A or IL-17F Is Sufficient to Maintain Innate Response and Control of Helicobacter pylori Immunopathogenesis.  |  Dixon, BREA., et al. 2022. Immunohorizons. 6: 116-129. PMID: 35144998
8. Interleukin-17 signaling influences CD8+ T cell immunity and tumor progression according to the IL-17 receptor subunit expression pattern in cancer cells.  |  Rodriguez, C., et al. 2023. Oncoimmunology. 12: 2261326. PMID: 37808403
9. IL-17 receptor A functions to help maintain barrier integrity and limit activation of immunopathogenic response to H. pylori infection.  |  Brackman, LC., et al. 2024. Infect Immun. 92: e0029223. PMID: 38014948
10. Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats.  |  Arenas, YM., et al. 2024. Biol Res. 57: 18. PMID: 38671534

The preferred IL-17R antibody is IL-17R Antibody (G-9): sc-376374.