IL-12B p40 Antibody (1-1A4): sc-53348
- IL-12B p40 Antibody (1-1A4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against recombinant human IL-12
- recommended for detection of IL-12B p40 of human origin by WB, IP and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IL-12B p40 Antibody (1-1A4) for WB applications. These reagents are now offered in bundles with IL-12B p40 Antibody (1-1A4) (see ordering information below).
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IL-12B p40 Antibody (1-1A4) is a mouse monoclonal IgG1 antibody that detects IL-12B p40 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IL-12B p40 plays a crucial role in the immune response as a subunit of the heterodimeric cytokine IL-12, which is essential for the differentiation of naive CD4(+) T cells into type 1 helper T cells that produce interferon-γ (IFN-γ). This process is vital for the activation of T and natural killer (NK) cells, which are key players in the body′s defense against infections and tumors. Additionally, IL-12B p40 can combine with p19 to form IL-23, another important cytokine that shares some functional properties with IL-12, including the activation of the transcription factor Stat4 and the promotion of IFN-γ production. IL-12B p40′s ability to influence both IL-12 and IL-23 pathways highlights its significance in regulating immune responses and maintaining immune homeostasis. Anti-IL-12B p40 antibody (1-1A4) serves as an invaluable tool for researchers studying cytokine signaling and immune system dynamics.
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IL-12B p40 Antibody (1-1A4) References:
- The IL12B gene is associated with asthma. | Randolph, AG., et al. 2004. Am J Hum Genet. 75: 709-15. PMID: 15322986
- Association between IL12B polymorphisms and tuberculosis risk: a meta-analysis. | Liu, G., et al. 2014. Infect Genet Evol. 21: 401-7. PMID: 24365584
- IL12B (p40) Gene Polymorphisms Contribute to Ustekinumab Response Prediction in Psoriasis. | Galluzzo, M., et al. 2016. Dermatology. 232: 230-6. PMID: 26678060
- Increased expression of IL12B mRNA transcribed from the risk haplotype for Crohn's disease is a risk factor for disease relapse in Japanese patients. | Kakuta, Y., et al. 2017. J Gastroenterol. 52: 1230-1239. PMID: 28229296
- Effect of polymorphisms in IL-12B p40, IL-17A and IL-23 A/G genes on the response of psoriatic patients to narrowband UVB. | Youssef, R., et al. 2018. Photodermatol Photoimmunol Photomed. 34: 347-349. PMID: 29763989
- DNA methylation and transcriptome signature of the IL12B gene in ankylosing spondylitis. | Zhang, X., et al. 2019. Int Immunopharmacol. 71: 109-114. PMID: 30889422
- IL12B and IL23R polymorphisms are associated with alopecia areata. | Tabatabaei-Panah, PS., et al. 2020. Genes Immun. 21: 203-210. PMID: 32355229
- Regulation of IL12B Expression in Human Macrophages by TALEN-mediated Epigenome Editing. | Chen, M., et al. 2020. Curr Med Sci. 40: 900-909. PMID: 33123904
- A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis. | Kadoba, K., et al. 2021. Sci Rep. 11: 13667. PMID: 34211061
- Leukocytoclastic vasculitis in patients with IL12B or IL12RB1 deficiency: case report and review of the literature. | Sharifinejad, N., et al. 2021. Pediatr Rheumatol Online J. 19: 121. PMID: 34389021
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-12B p40 Antibody (1-1A4) | sc-53348 | 200 µg/ml | $322.00 | |||
IL-12B p40 Antibody (1-1A4): m-IgG Fc BP-HRP Bundle | sc-536939 | 200 µg Ab; 10 µg BP | $361.00 | |||
IL-12B p40 Antibody (1-1A4): m-IgGκ BP-HRP Bundle | sc-534115 | 200 µg Ab; 40 µg BP | $361.00 | |||
IL-12B p40 Antibody (1-1A4): m-IgG1 BP-HRP Bundle | sc-544912 | 200 µg Ab; 20 µg BP | $361.00 |