IL-12B p40 Antibody (F-10): sc-365389

IL-12B p40 Antibody (F-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects IL-12B p40 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-12B p40 (F-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The interleukin-12 (IL-12) family, which includes IL-12B p40, plays a crucial role in the immune response, particularly in the differentiation of naive CD4(+) T cells into type 1 helper T cells that produce interferon-γ (IFN-γ). This process is vital for the immune system′s ability to combat intracellular pathogens and tumors. IL-12B p40 subunit is not only a component of IL-12 but also combines with p19 subunit to form IL-23, a cytokine that shares some functional properties with IL-12, such as the activation of transcription factor Stat4 and promotion of IFN-γ production. IL-12B p40′s ability to form these biologically active complexes underscores its importance in regulating immune responses and highlights anti-IL-12B p40 antibody (F-10)′s relevance in research focused on immunology and therapeutic interventions.

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IL-12B p40 Antibody (F-10) References:

1. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.  |  Oppmann, B., et al. 2000. Immunity. 13: 715-25. PMID: 11114383
2. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.  |  Wiekowski, MT., et al. 2001. J Immunol. 166: 7563-70. PMID: 11390512
3. IL-23: a cytokine that acts on memory T cells.  |  Frucht, DM. 2002. Sci STKE. 2002: pe1. PMID: 11784889
4. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present.  |  Cooper, AM., et al. 2002. J Immunol. 168: 1322-7. PMID: 11801672
5. Organic dust-induced interleukin-12 production activates T- and natural killer cells.  |  Muller-Suur, C., et al. 2002. Eur Respir J. 20: 686-90. PMID: 12358348
6. Antitumor and antimetastatic activity of IL-23.  |  Lo, CH., et al. 2003. J Immunol. 171: 600-7. PMID: 12847224
7. IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization.  |  Ha, SJ., et al. 2004. J Immunol. 172: 525-31. PMID: 14688363
8. Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.  |  Verreck, FA., et al. 2004. Proc Natl Acad Sci U S A. 101: 4560-5. PMID: 15070757
9. IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12.  |  Lieberman, LA., et al. 2004. J Immunol. 173: 1887-93. PMID: 15265921
10. Impact of IL12B gene rs 3212227 polymorphism on fibrosis, liver inflammation, and response to treatment in genotype 4 Egyptian hepatitis C patients.  |  Youssef, SS., et al. 2013. Dis Markers. 35: 431-7. PMID: 24223458
11. A novel susceptibility locus for Takayasu arteritis in the IL12B region can be a genetic marker of disease severity.  |  Matsumura, T., et al. 2016. Heart Vessels. 31: 1016-9. PMID: 25783557
12. Author Correction: Genotypic variability-based genome-wide association study identifies non-additive loci HLA-C and IL12B for psoriasis.  |  Wei, WH., et al. 2019. J Hum Genet. 64: 831. PMID: 31123311

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-12B p40 Antibody (F-10) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-12B p40 Antibody (F-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-12B p40 Antibody (F-10) Specifications

Alternate Product Name: IL-12B p40

Product Clone Name: F-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 23-328

Epitope Target: IL-12B p40

Epitope Species: human

Product Reactivity/Detection: IL-12B p40

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for IL-12B p40 Antibody (F-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin