IL-11Rα Antibody (H-3): sc-393227

IL-11Rα Antibody (H-3) is a mouse monoclonal IgG2a antibody that detects IL-11Rα in mouse and rat samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-11Rα, a crucial component of the interleukin-11 signaling pathway, plays a significant role in regulating immune responses and hematopoiesis. IL-11Rα is primarily located on the surface of various cell types, including mesenchymal and hematopoietic progenitor cells, where IL-11Rα facilitates IL-11 binding, leading to downstream signaling pathway activation that promotes cell proliferation and differentiation. IL-11Rα′s cellular location is essential for proper immune and skeletal system functioning, influencing processes such as inflammation and tissue repair. Additionally, IL-11Rα′s interaction with co-receptor gp130 is vital for high-affinity binding and subsequent signal transduction, underscoring intricate regulatory mechanisms that govern cellular responses to cytokines. With IL-11Rα′s ability to modulate critical biological processes in both normal physiology and pathological conditions, anti-IL-11Rα antibody (H-3) serves as an invaluable tool for researchers studying cytokine signaling and its implications in health and disease.

The preferred IL-11Rα antibody is IL-11Rα Antibody (4D12): sc-130920.