IL-11Rα Antibody (4D12): sc-130920

IL-11Rα Antibody (4D12) is a mouse monoclonal IgG1 kappa light chain antibody that detects IL-11R alpha protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-IL-11Rα antibody (4D12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-11Rα protein plays a crucial role in mediating the effects of the pleiotropic cytokine IL-11, which influences the proliferation and differentiation of lymphopoietic, myeloid, and erythroid cells. IL-11 has been shown to inhibit adipogenesis in vitro, highlighting IL-11′s importance in metabolic regulation. IL-11Rα receptor is a member of the class I cytokine receptor family and shares structural similarities with the alpha subunits of human ciliary neurotrophic factor and mouse IL-6 receptor. This structural similarity suggests a conserved mechanism of action among these receptors. High-affinity binding of IL-11 to IL-11Rα requires glycoprotein 130 (gp130) coexpression, which is essential for proper stimulation of Ba/F3 cells to differentiate into macrophages in response to IL-11. Understanding IL-11Rα interactions and functions is vital for elucidating IL-11Rα′s role in various physiological and pathological processes, making IL-11Rα (4D12) monoclonal antibody an invaluable tool for researchers studying cytokine signaling pathways.

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IL-11Rα Antibody (4D12) References:

1. IL-11 and IL-11Ralpha immunolocalisation at primate implantation sites supports a role for IL-11 in placentation and fetal development.  |  Dimitriadis, E., et al. 2003. Reprod Biol Endocrinol. 1: 34. PMID: 12740032
2. IL-11Rα: a novel target for the treatment of osteosarcoma.  |  Lewis, VO. 2014. Adv Exp Med Biol. 804: 285-9. PMID: 24924180
3. IL-11Rα-targeted nanostrategy empowers chemotherapy of relapsed and patient-derived osteosarcoma.  |  Jiang, J., et al. 2022. J Control Release. 350: 460-470. PMID: 36041590
4. The Emerging Role of Interleukin-(IL)-11/IL-11R in Bone Metabolism and Homeostasis: From Cytokine to Osteokine.  |  Dong, B., et al. 2023. Aging Dis. 14: 2113-2126. PMID: 37199584
5. Targeting IL-11 system as a treatment of pulmonary arterial hypertension.  |  Milara, J., et al. 2023. Pharmacol Res. 197: 106985. PMID: 37949331
6. Targeting IL-11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension-associated lung fibrosis.  |  Milara, J., et al. 2024. Br J Pharmacol. 181: 2991-3009. PMID: 38679415
7. The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors.  |  Jacobsen, SE., et al. 1995. J Exp Med. 181: 1357-63. PMID: 7535335
8. Murine marrow cells expanded in culture with IL-3, IL-6, IL-11, and SCF acquire an engraftment defect in normal hosts.  |  Peters, SO., et al. 1995. Exp Hematol. 23: 461-9. PMID: 7536685
9. IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology.  |  Keith, JC., et al. 1994. Stem Cells. 12 Suppl 1: 79-89; discussion 89-90. PMID: 7696971
10. Etl2, a novel putative type-I cytokine receptor expressed during mouse embryogenesis at high levels in skin and cells with skeletogenic potential.  |  Neuhaus, H., et al. 1994. Dev Biol. 166: 531-42. PMID: 7813775
11. Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.  |  Hilton, DJ., et al. 1994. EMBO J. 13: 4765-75. PMID: 7957045
12. Review of a novel hematopoietic cytokine, interleukin-11.  |  Quesniaux, VF., et al. 1993. Int Rev Exp Pathol. 34 Pt A: 205-14. PMID: 8454414

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-11Rα Antibody (4D12) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-11Rα Antibody (4D12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-11Rα Antibody (4D12) Specifications

Alternate Product Name: IL-11Rα

Product Clone Name: 4D12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: IL-11Rα

Epitope Species: human

Product Reactivity/Detection: IL-11Rα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for IL-11Rα Antibody (4D12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin