IL-10Rβ Antibody (B-4): sc-514822

IL-10Rβ Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects IL-10Rβ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-10Rβ plays a crucial role in the immune response by forming a heterodimeric receptor with IL-10Rα, which is essential for mediating the anti-inflammatory effects of interleukin-10 (IL-10). This receptor complex is vital for regulating immune responses, particularly in chronic inflammation and autoimmune diseases. IL-10Rβ expression is widespread, being found in various immune cells, including natural killer (NK) cells, where IL-10Rβ enhances cytokine production upon IL-10 binding. IL-10′s interaction with IL-10Rβ not only promotes immune cell survival and proliferation but also inhibits pro-inflammatory cytokine production, maintaining immune homeostasis. Anti-IL-10Rβ antibody (B-4) serves as an invaluable tool for researchers studying immune regulation mechanisms and the therapeutic potential of targeting IL-10 signaling pathways in various diseases.

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IL-10Rβ Antibody (B-4) References:

1. Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes.  |  Kotenko, SV., et al. 2001. J Biol Chem. 276: 2725-32. PMID: 11035029
2. Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation: synergism between IL-10 genotype of patient and IL-10 receptor beta genotype of donor.  |  Lin, MT., et al. 2005. Blood. 106: 3995-4001. PMID: 16109775
3. Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.  |  Sivula, J., et al. 2009. BMC Immunol. 10: 24. PMID: 19409109
4. Novel type III interferons produce anti-tumor effects through multiple functions.  |  Li, Q., et al. 2013. Front Biosci (Landmark Ed). 18: 909-18. PMID: 23747856
5. Polymorphism of IL-10 receptor β affects the prognosis of multiple myeloma patients treated with thalidomide and/or bortezomib.  |  Kasamatsu, T., et al. 2017. Hematol Oncol. 35: 711-718. PMID: 27405747
6. The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.  |  Mendoza, JL., et al. 2017. Immunity. 46: 379-392. PMID: 28329704
7. CD4+ T cell expression of the IL-10 receptor is necessary for facial motoneuron survival after axotomy.  |  Runge, EM., et al. 2020. J Neuroinflammation. 17: 121. PMID: 32303238
8. Knockout-Induced Pluripotent Stem Cells for Disease and Therapy Modeling of IL-10-Associated Primary Immunodeficiencies.  |  Sens, J., et al. 2021. Hum Gene Ther. 32: 77-95. PMID: 33023317
9. Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPsc-Derived Macrophages.  |  Hoffmann, D., et al. 2021. J Pers Med. 11: PMID: 33804706
10. IL-28A/IL-10Rβ axis promotes angiogenesis via eNOS/AKT signaling and AP-1/NF-κB/MMP-2 network by regulating HSP70-1 expression.  |  Song, JH., et al. 2024. J Adv Res.. PMID: 39127098

The preferred IL-10Rβ antibody is IL-10Rβ Antibody (F-6): sc-271969.