IL-10Rβ Antibody (F-6): sc-271969

IL-10Rβ Antibody (F-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects IL-10R beta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-10Rβ (F-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-10Rβ (F-6) monoclonal antibody targets a receptor that plays a crucial role in immune regulation by mediating the anti-inflammatory effects of interleukin-10 (IL-10), a cytokine vital for controlling immune responses and preventing excessive inflammation. IL-10Rβ is expressed in various immune cells, including B cells and T helper cells, and is essential for forming the functional IL-10 receptor complex. IL-10Rβ also forms heterodimers with IL-22R and IL-28R subunits, expanding its role in cytokine signaling. IL-10Rβ′s ability to modulate immune responses is particularly important in conditions such as autoimmune diseases and chronic inflammatory disorders, where IL-10 signaling can help restore balance and promote healing. IL-10Rβ is constitutively expressed on human natural killer (NK) cells, and direct interaction with IL-10 enhances cytokine production, highlighting its significance in innate immunity. anti-IL-10Rβ antibody (F-6) serves as a valuable tool for researchers studying the intricate mechanisms of immune regulation and the therapeutic potential of targeting IL-10 signaling pathways.

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IL-10Rβ Antibody (F-6) References:

1. Regulatory activity of autocrine IL-10 on dendritic cell functions.  |  Corinti, S., et al. 2001. J Immunol. 166: 4312-8. PMID: 11254683
2. Novel interferons.  |  Vilcek, J. 2003. Nat Immunol. 4: 8-9. PMID: 12496969
3. IL-10 signaling via IL-10E1 is dependent on tyrosine phosphorylation in the IL-10R alpha chain in human primary prostate cancer cell lines.  |  Stearns, ME., et al. 2003. Oncogene. 22: 3781-91. PMID: 12802285
4. Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2.  |  Sheikh, F., et al. 2004. J Immunol. 172: 2006-10. PMID: 14764663
5. Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.  |  Sivula, J., et al. 2009. BMC Immunol. 10: 24. PMID: 19409109
6. Polymorphism of IL-10 receptor β affects the prognosis of multiple myeloma patients treated with thalidomide and/or bortezomib.  |  Kasamatsu, T., et al. 2017. Hematol Oncol. 35: 711-718. PMID: 27405747
7. IL-28A/IL-10Rβ axis promotes angiogenesis via eNOS/AKT signaling and AP-1/NF-κB/MMP-2 network by regulating HSP70-1 expression.  |  Song, JH., et al. 2024. J Adv Res.. PMID: 39127098
8. The functional characterization of interleukin-10 receptor expression on human natural killer cells.  |  Carson, WE., et al. 1995. Blood. 85: 3577-85. PMID: 7540068
9. Functional regions of the mouse interleukin-10 receptor cytoplasmic domain.  |  Ho, AS., et al. 1995. Mol Cell Biol. 15: 5043-53. PMID: 7544437
10. Characterization of recombinant extracellular domain of human interleukin-10 receptor.  |  Tan, JC., et al. 1995. J Biol Chem. 270: 12906-11. PMID: 7759550
11. Lipopolysaccharide-dependent induction of IL-10 receptor expression on murine fibroblasts.  |  Weber-Nordt, RM., et al. 1994. J Immunol. 153: 3734-44. PMID: 7930590
12. A receptor for interleukin 10 is related to interferon receptors.  |  Ho, AS., et al. 1993. Proc Natl Acad Sci U S A. 90: 11267-71. PMID: 8248239

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-10Rβ Antibody (F-6) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-10Rβ Antibody (F-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-10Rβ Antibody (F-6) Specifications

Alternate Product Name: IL-10Rβ

Product Clone Name: F-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 251-281

Epitope Target: IL-10Rβ

Epitope Species: human

Product Reactivity/Detection: IL-10Rβ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for IL-10Rβ Antibody (F-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin