IL-10 Antibody (23738.11): sc-57244
- IL-10 Antibody (23738.11) is a mouse monoclonal IgG2b, cited in 1 publications, provided at 100 µg/ml
- raised against full length IL-10 of human origin
- recommended for detection of IL-10 of human origin by WB and ELISA
- See IL-10 (E-10): sc-8438 for IL-10 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-10 Antibody (23738.11). This work is in progress.
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IL-10 Antibody (23738.11) is a mouse monoclonal IgG2b antibody that detects interleukin-10 in human samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). IL-10 is a crucial cytokine primarily secreted by TH2 clones, playing a significant role in immune regulation by suppressing pro-inflammatory cytokine production from TH1 clones in response to antigens presented by monocyte and macrophage antigen presenting cells. This suppression helps maintain immune homeostasis and prevents excessive inflammatory responses that can lead to tissue damage. IL-10 exerts effects by binding to the IL-10 receptor, a glycoprotein induced in macrophages and fibroblasts upon lipopolysaccharide stimulation, highlighting importance in modulating immune responses during infections and inflammatory conditions. Anti-IL-10 antibody (23738.11) proves particularly valuable for researchers studying IL-10′s role in various diseases, including elevated expression in HIV-1 infected individuals, where IL-10 has been implicated in disease progression. With detection capabilities for both human and murine IL-10, which share significant sequence identity, anti-IL-10 antibody (23738.11) serves as an essential tool for advancing understanding of cytokine signaling and immune regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-10 Antibody (23738.11) References:
- IL-10, T cell exhaustion and viral persistence. | Blackburn, SD. and Wherry, EJ. 2007. Trends Microbiol. 15: 143-6. PMID: 17336072
- The role of microRNAs in the control and mechanism of action of IL-10. | Quinn, SR. and O'Neill, LA. 2014. Curr Top Microbiol Immunol. 380: 145-55. PMID: 25004817
- The molecular basis of IL-10 function: from receptor structure to the onset of signaling. | Walter, MR. 2014. Curr Top Microbiol Immunol. 380: 191-212. PMID: 25004819
- The paradoxical role of IL-10 in immunity and cancer. | Mannino, MH., et al. 2015. Cancer Lett. 367: 103-7. PMID: 26188281
- IL-10 Has Differential Effects on the Innate and Adaptive Immune Systems of Septic Patients. | Mazer, M., et al. 2019. J Immunol. 203: 2088-2099. PMID: 31501258
- Immune regulation and cytotoxic T cell activation of IL-10 agonists - Preclinical and clinical experience. | Oft, M. 2019. Semin Immunol. 44: 101325. PMID: 31706853
- Human IL-10-producing B cells have diverse states that are induced from multiple B cell subsets. | Glass, MC., et al. 2022. Cell Rep. 39: 110728. PMID: 35443184
- Implication of the IL-10-Expression Signature in the Pathogenicity of Leptospira-Infected Macrophages. | Chou, LF., et al. 2022. Microbiol Spectr. 10: e0259521. PMID: 35638785
- Sustained delivery of IL-10 by self-assembling peptide hydrogel to reprogram macrophages and promote diabetic alveolar bone defect healing. | Wang, C., et al. 2023. Dent Mater. 39: 418-429. PMID: 36931990
- Tox induces T cell IL-10 production in a BATF-dependent manner. | Canaria, DA., et al. 2023. Front Immunol. 14: 1275423. PMID: 38054003
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-10 Antibody (23738.11) | sc-57244 | 100 µg/ml | $322.00 |