IKKγ Antibody (1.T.26): sc-71331

IKKγ Antibody (1.T.26) is a mouse monoclonal IgG1 antibody engineered to recognize the full-length His-tagged IKKγ protein, also known as NEMO (NF-κB Essential Modulator), of human origin. Anti-IKKγ antibody (1.T.26) is optimized for applications such as western blotting (WB) and immunoprecipitation (IP), ensuring reliable detection of IKKγ in various research settings. IKKγ is a crucial regulatory subunit of the IKK complex, which is essential for the activation of the NF-κB signaling pathway, a key mediator of immune responses and inflammation. Structurally, IKKγ contains multiple zinc finger motifs and a ubiquitin-binding domain, facilitating interactions with other proteins and maintaining the structural integrity of the IKK complex. Post-translational modifications, particularly ubiquitination, play a significant role in regulating IKKγ′s activity, stability, and interactions with kinases like IKKα and IKKβ, thereby controlling the phosphorylation and degradation of IκB inhibitors. These modifications are vital for the proper activation of NF-κB, allowing translocation to the nucleus and activation of genes involved in cell survival and immune responses. Additionally, IKKγ interacts with various ubiquitin ligases and kinases, which are essential for function in signal transduction and cellular responses to proinflammatory cytokines. By targeting the full-length native IKKγ, IKKγ monoclonal antibody (1.T.26) enables researchers to investigate the dynamic interactions and modifications of this protein, providing insights into its role in diseases such as cancer, autoimmune disorders, and chronic inflammation. Anti-IKKγ antibody (1.T.26) is an indispensable tool for advancing studies in molecular biology and immunology, facilitating a deeper understanding of the molecular mechanisms governing NF-κB activation and cellular responses.

The preferred IKKγ antibody is IKKγ Antibody (B-3): sc-8032.