Date published: 2025-10-4

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IKK Activators

Santa Cruz Biotechnology now offers a broad range of IKK Activators for use in various applications. IKK Activators are essential tools for studying the function and regulation of the IκB kinase (IKK) complex, which plays a pivotal role in the activation of the NF-κB signaling pathway. This pathway is crucial for regulating immune responses, inflammation, and cell survival. By specifically activating IKK, researchers can investigate the pathways and mechanisms through which this kinase complex influences various cellular processes. In scientific research, IKK Activators are used to explore the downstream effects of IKK activation on gene expression, cytokine production, and cellular responses to stress and pathogens. These activators help explain the role of IKK in modulating immune and inflammatory responses, providing insights into how IKK activity affects NF-κB translocation to the nucleus and subsequent transcription of target genes. Additionally, these activators are valuable in high-throughput screening assays aimed at discovering new modulators of IKK activity, aiding in the identification of novel regulatory mechanisms and potential research targets. The use of IKK Activators supports the development of experimental models to dissect the complex signaling networks involving IKK and NF-κB. By enabling precise control over IKK activity, these activators facilitate comprehensive studies of the kinase complex's role in cellular physiology and its broader implications in various biological contexts. View detailed information on our available IKK Activators by clicking on the product name.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Prostratin

60857-08-1sc-203422
sc-203422A
1 mg
5 mg
$138.00
$530.00
24
(2)

Prostratin acts as an inhibitor of IκB kinase (IKK), engaging in specific interactions with the enzyme's active site. This binding modulates the phosphorylation of IκB proteins, thereby influencing the NF-κB signaling pathway. Prostratin's unique molecular structure allows it to stabilize the enzyme-substrate complex, affecting reaction kinetics and enhancing the selectivity of IKK inhibition. Its distinct conformational dynamics contribute to the regulation of cellular responses to stress and inflammation.