Anti-IKK-ε Antibody (A-11) is a mouse monoclonal IgG2a κ IKK-ε antibody, cited in 9 publications, provided at 200 µg/ml
specific for an epitope mapping between amino acids 2-24 at the N-terminus of IKK-ε of human origin
Anti-IKK-epsilon Antibody (A-11) is recommended for detection of IKK-ε of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
Anti-IKK-epsilon Antibody (A-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of IKK-ε (A-11): sc-376114.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for IKK-ε Antibody (A-11) for WB and IHC(P) applications. This reagent is now offered in a bundle with IKK-ε Antibody (A-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
IKK-ε Antibody (A-11) is a high quality monoclonal IKK-ε antibody (also designated IKK epsilon antibody, IKBKE antibody, IKKE antibody or IKKI antibody) suitable for the detection of the IKK-ε protein of mouse, rat and human origin. IKK-ε Antibody (A-11) is available as both the non-conjugated anti-IKK-ε antibody form, as well as multiple conjugated forms of anti-IKK-ε antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The transcription factor NFκB is retained in the cytoplasm in an inactive form by the inhibitory protein IκB. Activation of NFκB requires that IκB be phosphorylated on specific serine residues, which results in targeted degradation of IκB. IκB kinase α (IKKα), previously designated CHUK, interacts with IκB-α and specifically phosphorylates IκB-α on the sites that trigger its degradation, Serines 32 and 36. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ (also designated NEMO), and each appear to make essential contributions to IκB phosphorylation. IKK-ε, also designated IKK-i or IKBKE, is a serine/threonine kinase that shares homology with IKKα and IKKβ. IKK-ε is primarily expressed in immune cells and is induced by lipopolysaccharide and by proinflammatory cytokines including TNFα, IL-1 and IL-6. Overexpression of IKK-ε has been shown to result in phosphorylation of IκBα on Ser 32 and Ser 36, and in NFκB activation, suggesting that IKK-ε may act as an IκB kinase in the immune system.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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