IKK alpha Antibody (14A231): sc-52932

IKKα Antibody (14A231) is a mouse monoclonal IgG1 kappa light chain antibody that detects IKKα in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-IKKα antibody (14A231) is available in a non-conjugated form, allowing for versatile use in various experimental setups. IKKα, also known as CHUK, plays a pivotal role in activating the transcription factor NFκB, which regulates immune responses and inflammation. Located primarily in the cytoplasm, IKKα phosphorylates the inhibitory protein IκB on specific serine residues, leading to IκB degradation and subsequent NFκB release into the nucleus. This process enables NFκB to translocate and activate genes involved in immune and inflammatory responses. NFκB-inducing kinase (NIK) stimulates IκB phosphorylation by IKKα, serving as a key regulator in signaling pathways activated by tumor necrosis factor (TNF) and interleukin-1 (IL-1). The functional IKK complex, comprising IKKα, IKKβ, and IKKγ (NEMO), is essential for IκB phosphorylation, highlighting IKKα′s role in maintaining cellular homeostasis and responding to inflammatory stimuli.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IKK alpha Antibody (14A231) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-IKK alpha Antibody (14A231) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IKK alpha Antibody (14A231) Specifications

Alternate Product Name: IKK alpha

Product Clone Name: 14A231

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: IKKα

Epitope Species: human

Product Reactivity/Detection: IKKα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for IKK alpha Antibody (14A231): N/A

The preferred IKK alpha antibody is IKK alpha Antibody (B-8): sc-7606.