IκB-β Antibody (D-8): sc-74452
- IκB-β Antibody (D-8) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-359 representing full length IκB-β of mouse origin
- recommended for detection of IκB-β of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications (sc-74452 X, 200 µg/0.1 ml)
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IκB-β Antibody (D-8) for WB applications. These reagents are now offered in bundles with IκB-β Antibody (D-8) (see ordering information below).
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IκB-β Antibody (D-8) is a mouse monoclonal IgG2b light chain antibody that detects IκB-β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IκB-β plays a crucial role in the regulation of the NF-κB signaling pathway, which is essential for controlling immune responses, inflammation, and cell survival. By sequestering NF-κB dimers in the cytoplasm, IκB-β prevents their translocation to the nucleus, thereby inhibiting the transcription of target genes involved in these processes. The importance of IκB-β extends to its involvement in various post-translational modifications, including phosphorylation, which can influence stability and the release of NF-κB. Understanding these modifications is vital, as they can affect the dynamics of NF-κB activation and have implications in diseases such as cancer and autoimmune disorders. Anti-IκB-β antibody (D-8) is an invaluable tool for researchers studying the intricate mechanisms of NF-κB regulation and its impact on cellular functions.
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IκB-β Antibody (D-8) References:
- Regulation of IkappaBbeta expression in testis. | Budde, LM., et al. 2002. Mol Biol Cell. 13: 4179-94. PMID: 12475944
- RelA/p65 regulation of IkappaBbeta. | Hertlein, E., et al. 2005. Mol Cell Biol. 25: 4956-68. PMID: 15923614
- p65 controls NF-κB activity by regulating cellular localization of IκBβ. | Valovka, T. and Hottiger, MO. 2011. Biochem J. 434: 253-63. PMID: 21158742
- IκBβ-mediated NF-κB activation confers protection against hyperoxic lung injury. | Michaelis, KA., et al. 2014. Am J Respir Cell Mol Biol. 50: 429-38. PMID: 24066808
- Inhibiting IκBβ-NFκB signaling attenuates the expression of select pro-inflammatory genes. | McKenna, S. and Wright, CJ. 2015. J Cell Sci. 128: 2143-55. PMID: 25908863
- IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer. | Tsui, R., et al. 2015. Nat Commun. 6: 7068. PMID: 25946967
- Syntaxin 4 Mediates NF-κB Signaling and Chemokine Ligand Expression via Specific Interaction With IκBβ. | Veluthakal, R., et al. 2021. Diabetes. 70: 889-902. PMID: 33526588
- Selective Hypoxia-Sensitive Oxomer Formation by FIH Prevents Binding of the NF-κB Inhibitor IκBβ to NF-κB Subunits. | Volkova, YL., et al. 2024. Mol Cell Biol. 44: 138-148. PMID: 38644795
- A sustained reduction in IkappaB-beta may contribute to persistent NF-kappaB activation in human endothelial cells. | Johnson, DR., et al. 1996. J Biol Chem. 271: 16317-22. PMID: 8663191
- Inhibition of IkappaB-alpha and IkappaB-beta proteolysis by calpain inhibitor I blocks nitric oxide synthesis. | Milligan, SA., et al. 1996. Arch Biochem Biophys. 335: 388-95. PMID: 8914937
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IκB-β Antibody (D-8) | sc-74452 | 200 µg/ml | $322.00 | |||
IκB-β Antibody (D-8): m-IgGκ BP-HRP Bundle | sc-534441 | 200 µg Ab; 40 µg BP | $361.00 | |||
IκB-β Antibody (D-8): m-IgG2b BP-HRP Bundle | sc-549254 | 200 µg Ab; 10 µg BP | $361.00 | |||
IκB-β Antibody (D-8) X | sc-74452 X | 200 µg/0.1 ml | $322.00 |