IGTP Antibody (7): sc-136317

IGTP Antibody (7) is a mouse monoclonal IgG1 kappa light chain antibody that detects IGTP protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-IGTP antibody (7) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). IGTP protein is a member of a distinct family of interferon-γ (IFN-γ) inducible GTPases, which play a crucial role in mediating cellular innate immune responses. These GTPases, which also include TGTP, IRG-47, and LRG-47, are selectively induced by IFN-γ or bacterial lipopolysaccharide (LPS) stimulation and are characterized by a nucleotide-binding domain essential for GTP binding and hydrolysis. The structural features of IGTP and related proteins, which exhibit significant sequence similarity and similar sizes, are vital for their function in immune response regulation. IGTP is predominantly expressed in macrophages, highlighting its importance in the innate immune system, while TGTP is specifically up-regulated in T-cells in response to T-cell receptor cross-linking. The differential expression patterns of these proteins underscore their specialized roles in immune signaling pathways, making anti-IGTP antibody (7) an invaluable tool for researchers studying immune responses in various contexts.

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IGTP Antibody (7) References:

1. Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.  |  Taylor, GA., et al. 2000. Proc Natl Acad Sci U S A. 97: 751-5. PMID: 10639151
2. The IRG-47 gene is IFN-gamma induced in B cells and encodes a protein with GTP-binding motifs.  |  Gilly, M. and Wall, R. 1992. J Immunol. 148: 3275-81. PMID: 1578148
3. GTP-binding domain: three consensus sequence elements with distinct spacing.  |  Dever, TE., et al. 1987. Proc Natl Acad Sci U S A. 84: 1814-8. PMID: 3104905
4. Identification of an endotoxin and IFN-inducible cDNA: possible identification of a novel protein family.  |  Sorace, JM., et al. 1995. J Leukoc Biol. 58: 477-84. PMID: 7561525
5. Isolation of a gene encoding a developmentally regulated T cell-specific protein with a guanine nucleotide triphosphate-binding motif.  |  Carlow, DA., et al. 1995. J Immunol. 154: 1724-34. PMID: 7836757
6. Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma.  |  Taylor, GA., et al. 1996. J Biol Chem. 271: 20399-405. PMID: 8702776
7. Identification of a lipopolysaccharide inducible transcription factor in murine macrophages.  |  Drysdale, BE., et al. 1996. Mol Immunol. 33: 989-98. PMID: 8960123
8. Two families of GTPases dominate the complex cellular response to IFN-gamma.  |  Boehm, U., et al. 1998. J Immunol. 161: 6715-23. PMID: 9862701

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IGTP Antibody (7) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-IGTP Antibody (7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IGTP Antibody (7) Specifications

Alternate Product Name: IGTP

Product Clone Name: 7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 283-423

Epitope Target: IGTP

Epitope Species: mouse

Product Reactivity/Detection: IGTP

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for IGTP Antibody (7): AC: Agarose, HRP: Horseradish Peroxidase