IGTP Activators
IGTP activators are a class of chemicals that enhance the activity of the Interferon Gamma Induced GTPase (IGTP), a protein implicated in the immune response against intracellular pathogens. These activators can exert their effects through both direct and indirect mechanisms, ultimately leading to an upregulation of IGTP's activity within cells. Direct activators may bind to the IGTP protein and induce a conformational change that increases its GTPase activity, thereby enhancing its ability to hydrolyze GTP to GDP. This increased activity can have a profound impact on the protein's role in the immune system, as GTPase activity is fundamental to the function of IGTP in pathogen control and clearance.
Indirect activators of IGTP, on the other hand, may work by upregulating the expression of the IGTP gene or by modulating the signaling pathways that control its activity. These could include compounds that increase the transcription of the IGTP gene through the activation of transcription factors or signaling molecules that lead to the upregulation of gene expression. For example, a compound that activates the JAK-STAT pathway, which is known to be involved in the response to interferon-gamma, might increase the synthesis of IGTP. Similarly, the activation of pathways that lead to post-translational modifications of the IGTP protein, such as phosphorylation, can enhance its activity by promoting its proper localization within the cell or its interaction with other proteins involved in immune responses.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. cAMP activates protein kinase A (PKA), which is known to phosphorylate various proteins, potentially enhancing IGTP activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol activates beta-adrenergic receptors, which stimulate adenylate cyclase to produce cAMP. Increased cAMP activates PKA, potentially enhancing IGTP activity through phosphorylation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine activates alpha-adrenergic receptors, leading to increased intracellular calcium levels. Calcium can stimulate various kinases that may phosphorylate and enhance IGTP activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is a coenzyme in redox reactions, driving ATP production. Increased ATP may provide the energy needed for kinases to phosphorylate IGTP, enhancing its activity. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $38.00 $74.00 | 9 | |
ATP provides the phosphate groups for protein kinases like PKA and PKG. Increased ATP availability could enhance the phosphorylation and thus the activity of IGTP. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can stimulate various kinases. These kinases may phosphorylate and enhance IGTP activity. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
CaCl2 increases intracellular calcium levels which can stimulate kinases that may phosphorylate and enhance IGTP activity. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol inhibits PDE3, leading to increased cAMP levels. Elevated cAMP stimulates PKA, potentially increasing IGTP activity through phosphorylation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits PDE4, leading to increased cAMP levels. Elevated cAMP activates PKA, potentially enhancing IGTP activity through phosphorylation. | ||||||
Theobromine | 83-67-0 | sc-203296 sc-203296A | 25 g 100 g | $41.00 $87.00 | ||
Theobromine inhibits PDEs, leading to increased cAMP and cGMP levels. These cyclic nucleotides activate PKA and PKG respectively, potentially enhancing IGTP activity through phosphorylation. | ||||||