IGF2BP3 Antibody (D-7): sc-390639
- IGF2BP3 Antibody (D-7) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 377-413 mapping near the C-terminus of IGF2BP3 of human origin
- Anti-IGF2BP3 Antibody (D-7) is recommended for detection of IGF2BP3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine
- Anti-IGF2BP3 Antibody (D-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IGF2BP3 Antibody (D-7) for WB and IHC(P) applications. These reagents are now offered in bundles with IGF2BP3 Antibody (D-7) (see ordering information below).
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SEE ALSO...
IGF2BP3 Antibody (D-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects IGF2BP3 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IGF2BP3 (D-7) antibody is available in non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. The insulin-like growth factor 2 mRNA binding proteins (IGF2BPs) play a crucial role in regulating RNA metabolism and synthesis, vital for cellular growth and differentiation. IGF2BP3 interacts with several key proteins, including c-Myc and IGF-II, essential for cell proliferation and survival. IGF2BP3′s binding to these mRNAs influences their stability and affects translation, impacting various cellular processes. IGF2BP3 shows high expression in various cancers, including colon, breast, and sarcomas, making anti-IGF2BP3 antibody (D-7) a significant marker for tumor progression and potential therapeutic intervention. IGF2BP3 knockdown reduces IGF-II protein levels without altering mRNA levels of IGF-II, c-Myc, or β-Actin, highlighting a specific regulatory role in mRNA translation. IGF2BP3 (D-7) monoclonal antibody serves as a valuable tool for researchers investigating molecular mechanisms underlying cancer biology and RNA metabolism.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IGF2BP3 Antibody (D-7) References:
- Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis. | Hanniford, D., et al. 2020. Cancer Cell. 37: 55-70.e15. PMID: 31935372
- Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p. | Yu, YZ., et al. 2022. Mol Cancer. 21: 12. PMID: 34986849
- EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3. | Pan, Z., et al. 2022. Mol Cancer. 21: 16. PMID: 35031058
- CircARID1A binds to IGF2BP3 in gastric cancer and promotes cancer proliferation by forming a circARID1A-IGF2BP3-SLC7A5 RNA-protein ternary complex. | Ma, Q., et al. 2022. J Exp Clin Cancer Res. 41: 251. PMID: 35986300
- CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability. | Yang, F., et al. 2023. J Transl Med. 21: 402. PMID: 37340423
- The IGF2BP3-COPS7B Axis Facilitates mRNA Translation to Drive Colorectal Cancer Progression. | Tang, J., et al. 2023. Cancer Res. 83: 3593-3610. PMID: 37560971
- Parkin regulates IGF2BP3 through ubiquitination in the tumourigenesis of cervical cancer. | Sun, X., et al. 2023. Clin Transl Med. 13: e1457. PMID: 37877353
- circRARS synergises with IGF2BP3 to regulate RNA methylation recognition to promote tumour progression in renal cell carcinoma. | Liu, Y., et al. 2023. Clin Transl Med. 13: e1512. PMID: 38073586
- Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma. | Dai, W., et al. 2024. Nat Commun. 15: 131. PMID: 38167409
- IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development. | Lv, L., et al. 2024. Cell Mol Biol Lett. 29: 39. PMID: 38504159
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IGF2BP3 Antibody (D-7) | sc-390639 | 200 µg/ml | $322.00 | |||
IGF2BP3 Antibody (D-7): m-IgG Fc BP-HRP Bundle | sc-530211 | 200 µg Ab; 10 µg BP | $361.00 | |||
IGF2BP3 Antibody (D-7): m-IgGκ BP-HRP Bundle | sc-523614 | 200 µg Ab, 40 µg BP | $361.00 | |||
IGF2BP3 Antibody (D-7): m-IgG1 BP-HRP Bundle | sc-543932 | 200 µg Ab; 20 µg BP | $361.00 | |||
IGF2BP3 Antibody (D-7) AC | sc-390639 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IGF2BP3 Antibody (D-7) HRP | sc-390639 HRP | 200 µg/ml | $322.00 | |||
IGF2BP3 Antibody (D-7) FITC | sc-390639 FITC | 200 µg/ml | $336.00 | |||
IGF2BP3 Antibody (D-7) PE | sc-390639 PE | 200 µg/ml | $349.00 | |||
IGF2BP3 Antibody (D-7) Alexa Fluor® 488 | sc-390639 AF488 | 200 µg/ml | $364.00 | |||
IGF2BP3 Antibody (D-7) Alexa Fluor® 546 | sc-390639 AF546 | 200 µg/ml | $364.00 | |||
IGF2BP3 Antibody (D-7) Alexa Fluor® 594 | sc-390639 AF594 | 200 µg/ml | $364.00 | |||
IGF2BP3 Antibody (D-7) Alexa Fluor® 647 | sc-390639 AF647 | 200 µg/ml | $364.00 | |||
IGF2BP3 Antibody (D-7) Alexa Fluor® 680 | sc-390639 AF680 | 200 µg/ml | $364.00 | |||
IGF2BP3 Antibody (D-7) Alexa Fluor® 790 | sc-390639 AF790 | 200 µg/ml | $364.00 |